中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (22): 4687-4693.doi: 10.12307/2025.456

• 组织工程口腔材料 tissue-engineered oral materials • 上一篇    下一篇

不同材料种植体修复单颗上前牙缺失的三维有限元分析

夏昭鑫1，2，高亦辰1，2，邓雨瑶1，2，王  霞1，2，兰小蓉2，何  芸1，2，陈俊良1，2   

  1. 1西南医科大学附属口腔医院口腔颌面外科，四川省泸州市   646000；2口颌面修复重建和再生泸州市重点实验室，四川省泸州市   646000
  • 收稿日期:2024-04-18 接受日期:2024-06-21 出版日期:2025-08-08 发布日期:2024-12-05
  • 通讯作者: 陈俊良，博士，主任医师，硕士生导师，西南医科大学附属口腔医院口腔颌面外科，四川省泸州市 646000；口颌面修复重建和再生泸州市重点实验室，四川省泸州市 646000
  • 作者简介:夏昭鑫，男，1998年生，四川省泸州市人，汉族，硕士，主要从事牙槽外科学研究。
  • 基金资助:
    四川省科技厅项目(2022YFS0634)，课题名称：颅颌面病理性骨缺损的骨修复再生，项目负责人：兰小蓉；四川省科技厅项目(2022YFS0282)，课题名称：基于牙囊干细胞的 3D 打印个性化人工骨制备及其促进牙槽骨缺损修复的机制研究，项目负责人：何芸；泸州市科技局项目(2023SYF116)，课题名称：新型光热抗菌柔性水凝胶创面敷料的研发与应用研究(面上)，项目负责人：陈俊良；泸州市科技局项目(2023WGR169)，课题名称：口腔种植的基础和临床相关研究，项目负责人：何芸； 叙州区-西南医科大学项目(2021XZXNYD02)，课题名称：基于叙州区早茶提取物和Cu2+的新型骨组织工程支架材料的研制，项目负责人：陈俊良

Three-dimensional finite element analysis of different material implants for replacing single missing anterior tooth

Xia Zhaoxin1, 2, Gao Yichen1, 2, Deng Yuyao1, 2, Wang Xia1, 2, Lan Xiaorong2, He Yun1, 2, Chen Junliang1, 2   

  1. 1Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Southwest Medical University, Luzhou 646000, Sichuan Province, China; 2Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Luzhou 646000, Sichuan Province, China
  • Received:2024-04-18 Accepted:2024-06-21 Online:2025-08-08 Published:2024-12-05
  • Contact: Chen Junliang, MD, Chief physician, Master’s supervisor, Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Southwest Medical University, Luzhou 646000, Sichuan Province, China; Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Luzhou 646000, Sichuan Province, China
  • About author:Xia Zhaoxin, Master, Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital, Southwest Medical University, Luzhou 646000, Sichuan Province, China; Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Luzhou 646000, Sichuan Province, China
  • Supported by:
    a grant from Sichuan Science and Technology Department, No. 2022YFS0634 (to LXR); a grant from Sichuan Science and Technology Department, No. 2022YFS0282 (to HY); Luzhou Science and Technology Bureau Project, No. 2023SYF116 (to CJL); Luzhou Science and Technology Bureau Project, No. 2023WGR169 (to HY); Xuzhou District-Southwest Medical University Project, No. 2021XZXNYD02 (to CJL)

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摘要：


文题释义：

不同材料种植体：种植体已被广泛应用于牙齿缺失的修复，种植材料的选择对修复效果有重要影响，目前用于临床的种植材料包括金属、陶瓷、生物材料等。

三维有限元分析：通过将复杂的三维结构分割成许多小的有限元素，利用数学方程描述这些元素之间的相互作用关系，从而模拟和预测结构在外部载荷下的应力、应变等物理特性，是一种工程数值分析方法，用于研究三维结构的力学行为，在医学研究中应用广泛。


背景：种植修复已成为治疗前牙缺失的重要手段，选取合适的种植修复材料尤为重要，但目前临床应用的种植体材料均存在一定的不足，研究者们一直在探索合适的种植体材料。
目的：对比不同材料种植体修复单颗上前牙缺失的生物力学特征。
方法：将1例单颗上颌中切牙缺失患者的锥形束CT数据导入3-matic软件建立单颗上前牙缺失的三维有限元分析模型，将模型导入Marc Mentat中，根据不同的种植体材料(聚醚醚酮、钛锆合金、钛合金和氧化锆，4种材料的弹性模量依次升高)及松质骨密度(高密度、低密度)共设计8组种植体修复模型，模拟正中咬合时上前牙受力情况，比较分析种植体位移、应力以及骨皮质应力和骨松质应变。
结果与结论：①随着种植体材料弹性模量的增加，种植体的最大位移逐渐降低，聚醚醚酮组种植体最大位移数值超过了10 μm；模型中种植体应力集中于唇侧颈部，随着种植体材料弹性模量的增加，种植体最大应力逐渐增大，其中氧化锆-低密度骨质组模型种植体应力最高，达21.31 MPa；所有模型的皮质骨应力均集中于与种植体交界的唇侧皮质骨，聚醚醚酮-低密度骨质组皮质骨应力最高，为

29.90 MPa。②从生物力学角度来看，钛锆合金、钛合金、氧化锆均可用作修复单颗上前牙缺失的种植体材料，但单纯聚醚醚酮材料在上前牙区种植修复时可能会引起种植体位移过大，导致种植失败。

https://orcid.org/0009-0007-0333-1584 (夏昭鑫) 

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 三维有限元分析, 上前牙缺失, 种植体, 钛, 钛锆合金, 氧化锆, 聚醚醚酮

Abstract: BACKGROUND: Implant restoration has become an important means to treat anterior tooth loss, and it is particularly important to select appropriate implant restoration materials. However, at present, there are some deficiencies in clinical implant materials, and researchers have been exploring suitable implant materials.
OBJECTIVE: To compare the biomechanical characteristics of implants made of different materials in restoring single missing maxillary anterior teeth. 
METHODS: The cone beam CT data of a patient with single maxillary central incisor loss were imported into 3-matic software to establish a three-dimensional finite element analysis model of single maxillary anterior tooth loss. The model was then imported into Marc Mentat. Eight sets of implant restoration models were designed according to different implant materials (polyetheretherketone, titanium-zirconium alloy, titanium alloy, and zirconia, with the elastic modulus of the four materials increasing in sequence) and cancellous bone density (high density, low density) to simulate the stress conditions of the maxillary anterior teeth in centric occlusion. The total displacements and von Mises stresses of implants, cortical bone stresses and cancellous bone strains were compared and analyzed. 
RESULTS AND CONCLUSION: (1) The maximum displacement of the implant gradually decreased with the increase of the modulus of elasticity of the material, and the value of the maximum displacement of the implant in the polyetheretherketone group exceeded 10 μm; the implant stress was concentrated in the labial neck in the models. The maximum stress gradually increased with the increase of the modulus of elasticity of the implant material, among which, the zirconia-low density bone model had the highest stress, which was 21.31 MPa; the cortical bone stress was concentrated in the cortical bone at the junction of the implant with the labial side, and the polyetheretherketone-low density bone group had the highest value, which was 29.90 MPa. (2) From the biomechanical point of view, titanium-zirconium alloy, titanium alloy, and zirconia can be used as implant materials for restoration of a single missing anterior tooth, and implant displacement is one of the common problems during implant restorations, but pure polyetheretherketone material may cause excessive implant displacement in implant restorations of anterior areas, causing implant failure. 

Key words: three-dimensional finite element analysis, missing anterior tooth, implant, titanium, titanium-zirconia alloy, zirconia, polyetheretherketone

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