中国组织工程研究

中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (17): 2708-2715.doi: 10.12307/2024.373

• 生物材料综述 biomaterial review • 上一篇    下一篇

骨组织工程中促血管支架应用的可视化分析

方  源1，康志杰1，王海燕2，李筱贺2，张  凯3   

  1. 1内蒙古医科大学基础医学院，内蒙古自治区呼和浩特市  010000；2内蒙古医科大学基础医学院人体解剖教研室，内蒙古自治区呼和浩特市  010000；3乌兰察布市第二医院骨科，内蒙古自治区乌兰察布市  012000
  • 收稿日期:2023-04-25 接受日期:2023-06-02 出版日期:2024-06-18 发布日期:2023-12-15
  • 通讯作者: 王海燕，女，硕士，教授，硕士生导师，内蒙古医科大学基础医学院人体解剖教研室，内蒙古自治区呼和浩特市 010000 李筱贺，男，博士，教授，博士生导师，内蒙古医科大学基础医学院人体解剖教研室，内蒙古自治区呼和浩特市 010000
  • 作者简介:方源，女，1992年生，汉族，内蒙古自治区巴彦淖尔人，内蒙古医科大学在读硕士，主治医师，主要从事生物3D打印研究。
  • 基金资助:
    内蒙古自治区卫生健康科技项目(202201188)，项目负责人：王海燕；内蒙古自然科学基金(2021MS08086)，项目负责人：王海燕；内蒙古医科大学“成果转化”项目(YKD2020CGZH009)，项目负责人：王海燕；内蒙古自然科学基金(2020MS08124)，项目负责人：李筱贺；内蒙古自治区“草原英才”工程青年创新创业人才项目(2020)，项目负责人：李筱贺；内蒙古医科大学后续科研项目(2019)，项目负责人：李筱贺；2021年内蒙古医科大学致远人才项目，项目负责人：李筱贺；内蒙古医科大学2021年度校级科研重点项目(YKD2021ZD001)，项目负责人：李筱贺；内蒙古教育厅高等学校创新团队发展计划(NMGIRT2227)，项目负责人：李筱贺；乌兰察布市基础研究项目(2021JC321)，项目负责人：张凯

Visualization analysis of vascular stimulating scaffolds in bone tissue engineering#br#

Fang Yuan1, Kang Zhijie1, Wang Haiyan2, Li Xiaohe2, Zhang Kai3   

  1. 1School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China; 2Department of Human Anatomy, School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China; 3Department of Orthopedics, Second Hospital of Ulanqab, Ulanqab 012000, Inner Mongolia Autonomous Region, China
  • Received:2023-04-25 Accepted:2023-06-02 Online:2024-06-18 Published:2023-12-15
  • Contact: Wang Haiyan, Master, Professor, Master’s supervisor, Department of Human Anatomy, School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China Li Xiaohe, PhD, Professor, Doctoral supervisor, Department of Human Anatomy, School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China
  • About author:Fang Yuan, Master candidate, Attending physician, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China
  • Supported by:
    Health Science and Technology Project of Inner Mongolia Autonomous Region, No. 202201188 (to WHY); Inner Mongolia Natural Science Foundation, No. 2021MS08086 (to WHY); “Achievement Transformation” Project of Inner Mongolia Medical University, No. YKD2020CGZH009 (to WHY); Inner Mongolia Natural Science Foundation, No. 2020MS08124 (to LXH); Youth Innovation and Entrepreneurship Talent Project of “Grassland Talents” Project in Inner Mongolia Autonomous Region, No. 2020 (to LXH); Follow-up Research Project of Inner Mongolia Medical University, No. 2019 (to LXH); Zhiyuan Talent Project of Inner Mongolia Medical University in 2021 (to LXH); 2021 Key Scientific Research Project of Inner Mongolia Medical University, No. YKD2021ZD001 (to LXH); Development Plan for Innovation Teams in Higher Education Institutions of Inner Mongolia Department of Education, No. NMGIRT2227 (to LXH); Basic Research Project of Ulanqab City, No. 2021JC321 (to ZK)

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摘要：


文题释义：

骨组织工程：将种子细胞种植在特定支架上之后再植入人体，通过生物材料、细胞和因子的协同作用，诱导新的功能性骨再生，来修复、维持和改善受损骨组织。
促血管支架：植入体内后能够促进血管生成的生物材料支架。


背景：对于支架物理性质的研究始终是组织工程研究领域的热点，但对于促血管支架来说，除了要满足支架的基本性能外，还需要通过其他方法来促进血管在支架内的再生过程，以达到修复骨组织的最终目的。

目的：对国内外发表的骨组织工程下促血管支架的文献进行可视化分析，探究该领域的研究热点及研究现状，为后续研究提供参考。
方法：以中国知网及Web of Science核心集数据库为检索库，检索骨组织工程下促血管支架的相关文献，去除不符合纳入标准的文献，随后导入CiteSpace 6.1.R2软件，对研究领域的作者、国家机构及关键词进行可视化分析。

结果与结论：①骨组织工程下促血管支架应用的研究中，发文量最多的前3个国家分别为中国、美国和德国。②中国知网数据库机构该领域研究发文量排名前3位分别为南方医科大学、华中科技大学、东华大学；Web of Science核心集数据库中机构发文量排名前3位分别为上海交通大学、四川大学、中国科学院。③中国知网数据库关键词频次排名前3位为“组织工程、血管化、血管生成”，Web of Science核心集数据库关键词频次排名前3位为“mesenchymal stem cell(间充质干细胞)，scaffold(支架)，vascularization(血管化)”。④参考文献共被引情况和高被引文献分析显示，该领域的血管化策略研究热点为支架设计、血管生成因子的输送、体外共培养和体内预血管化；技术方面研究热点为3D打印、静电纺丝、血管移植及血管融合；机制方面研究热点为免疫调节和巨噬细胞、药物/生长因子输送、内皮细胞和成骨细胞之间的关系、骨细胞和内皮细胞之间旁分泌关系及信号分子通路、血管生成和抗血管生成分子。⑤国内外骨组织工程下促血管支架应用研究均十分重视干细胞和3D打印技术的运用，而目前的研究热点主要为生物3D打印技术、支架改性修饰的方法以及基于骨修复机制智能生物材料的开发应用。

https://orcid.org/0009-0008-4943-5917(方源)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 骨组织工程, 血管生成, 支架, 修饰, 3D打印, 生物材料, 干细胞, 复合支架, 智能生物材料, 可视化分析

Abstract: BACKGROUND: The study of the physical properties of scaffolds has always been a hot topic in the field of tissue engineering research. However, for vascular stimulating scaffolds, in addition to meeting the basic performance of the scaffold, other methods are also needed to promote the regeneration of blood vessels within the scaffold, in order to achieve the ultimate goal of repairing bone tissue.
OBJECTIVE: A visualization analysis was carried out on the literature published in and outside China on scaffold stimulation for bone tissue engineering, to explore the research hotspots and research status in this field, and to provide a reference for subsequent studies.
METHODS: Using the CNKI database and Web of Science core database as retrieval databases, the relevant literature on vascular scaffolds for bone tissue engineering was retrieved. The literature that did not conform to the research object was removed. The obtained data were imported into CiteSpace 6.1.R2 software. Visualization analysis was performed on authors, national institutions, and keywords in the research field. 
RESULTS AND CONCLUSION: (1) China, the United States, and Germany were the top three countries with the most articles on scaffold stimulation for bone tissue engineering. (2) The top 3 institutions in the CNKI database were Southern Medical University, Huazhong University of Science and Technology, and Donghua University. In the core database of Web of Science, Shanghai Jiao Tong University, Sichuan University and Chinese Academy of Sciences ranked the top 3 in terms of the number of institutional publications. (3) The top 3 keywords in the CNKI database were “tissue engineering, vascularization, angiogenesis”. The top 3 keywords in the Web of Science core database were “mesenchymal stem cell, scaffold, vascularization”. (4) Through the analysis of co-citation and highly cited references, the main concerns were as follows: vascularization strategies: scaffold design, angiogenic factor delivery, in vitro co-culture, and in vivo pre-vascularization. Technology: 3D printing, electrospinning, vascular transplantation, vascular fusion. Mechanisms: immune regulation and macrophages, drug/growth factor delivery, the relationship between endothelial cells and osteoblasts, the paracrine relationship between bone cells and endothelial cells, signaling molecular pathways, angiogenesis, and anti-angiogenesis molecules. (5) The researches concerning vascular stimulating scaffolds in bone tissue engineering in and outside China attach great importance to the application of stem cells and 3D printing technology. Current research focuses on biological 3D printing technology, scaffold modification methods, and the development and application of intelligent biomaterials based on bone repair mechanisms.

Key words: bone tissue engineering, angiogenesis, scaffold, modification, 3D printing, biomaterial, stem cell, composite scaffold, intelligent biomaterial, visualization analysis

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