Chinese Journal of Tissue Engineering Research ›› 2020, Vol. 24 ›› Issue (28): 4580-4587.doi: 10.3969/j.issn.2095-4344.2317
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Cardiac valve prosthesis implantation and surgical maze ablation for the treatment of valvular disease with atrial fibrillation
Ma Chao1, 2, Wang Huishan2, Han Jinsong2, Yin Zongtao2, Zhang Xiling1, 2
1Graduate School, General Hospital of Northern Theater Command, Jinzhou Medical University, Shenyang 110016, Liaoning Province, China; 2Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, Shenyang 110016, Liaoning Province, China
Received:
2019-12-05
Revised:
2019-12-10
Accepted:
2020-01-22
Online:
2020-10-08
Published:
2020-09-01
Contact:
Han Jinsong, MD, Associate chief physician, Master candidate, Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, Shenyang 110016, Liaoning Province, China
About author:
Ma Chao, Master candidate, Graduate School, General Hospital of Northern Theater Command, Jinzhou Medical University, Shenyang 110016, Liaoning Province, China; Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, Shenyang 110016, Liaoning Province, China
Supported by:
the Major Project of the Natural Science Foundation of Liaoning Province in 2017, No. 20170540977
CLC Number:
Ma Chao, Wang Huishan, Han Jinsong, Yin Zongtao, Zhang Xiling.
Cardiac valve prosthesis implantation and surgical maze ablation for the treatment of valvular disease with atrial fibrillation [J]. Chinese Journal of Tissue Engineering Research, 2020, 24(28): 4580-4587.
2.3 患者围术期情况 随访情况及并发症:324例患者均接受二尖瓣置换或瓣环成形术,二尖瓣置换材料以机械瓣为主,人工瓣环型号以32 mm较多。详见表2。术后4例患者(1.2%)因出血接受二次开胸手术,其病因均非迷宫手术切口引起。有2例患者(0.6%)在术后早期死亡,原因均为心力衰竭。其余所有患者均获得2年临床随访,随访期间无患者死亡和脑卒中,详见表3。术后2年,3例患者(0.9%)因窦性心动过缓需要永久性起搏器。 不良反应:瓣环成形患者无成形环断裂或撕脱、无溶血、左室流出道梗死、传导组织损伤。无再次手术行瓣膜置换患者。瓣膜置换患者无心内膜炎、非结构性功能障碍,结构性损伤,心肌缺血及血栓等发生。 植入材料与宿主反应 :①局部反应:本组病例均无局部炎症、刺激反应、过敏反应及组织增生;无材料腐蚀、磨损、生物降解、材料退化等。②全身反应:本组病例均无炎症和过敏现象,未发现细胞毒性、凝血改变、补体激活、致癌表现及免疫反应等。 "
2.4 生物相容性随访结果 322例患者均获得2年临床随访,随访期间无患者发生死亡和脑卒中。 2.4.1 窦性心律与左心房收缩功能 322例患者中,出院时298例患者(92.5%)获得窦性心律。出院至术后3个月,窦性心律与左心房收缩功能共存的一致性较差(Kappa系数<0.40,P < 0.05),表明此阶段大多数窦性心律不能伴随相应的左心房收缩功能。术后6个月时窦性心律与左心房收缩功能共存的一致性较一般(0.75>Kappa系数≥0.40,P < 0.05),术后12个月至术后2年,窦性心律与左心房收缩功能共存的一致性较好(Kappa系数≥0.75,P < 0.05),见图3,表4。术后2年,98.2%的窦性心律可伴随相应的左心房收缩功能。在不同时间的随访检查中,无相应左心房收缩功能的窦性心律患者无明显突出假体植入类型特征。 "
结合左心房收缩功能中晚期恢复预测因素结果绘制ROC曲线,见图4。术前心房颤动持续时间、术前左心房内径曲线下面积分别为 0.948,0.921,均大于0.9[95%CI (0.913,0.984),P < 0.001;95%CI(0.876,0.966),P <0.001]。术前心房颤动持续时间与术前左心房内径预测左心房收缩功能恢复的最佳临界值分别为36.5个月(敏感度90.5%,特异性93.7%),60.5 mm(敏感度93.8%,特异性85.0%)。Kaplan-Meier分析还证实,术前心房颤动持续时间<36.5个月、术前左心房内径<60.5 mm对迷宫手术后左心房收缩功能中晚期恢复具有重要的预测价值(Log rank test P均< 0.05),见图5A,B;人工瓣膜置换或瓣环植入并未对左心房收缩功能中晚期恢复造成影响(Log rank test P=0.120),见图5C。 "
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