中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (29): 5360-5362.doi: 10.3969/j.issn.1673-8225.2010.29.010

• 药物控释材料 drug delivery materials • 上一篇    下一篇

壳聚糖管状支架的制备及生物降解性

李雅勋1，陈  刚2，石文君2   

  1. 1辽宁医学院附属第一医院普外科，辽宁省锦州市   121001；2中国医科大学盛京医院胸外科，辽宁省沈阳市  110003
  • 出版日期:2010-07-16 发布日期:2010-07-16
  • 作者简介:李雅勋★，男，1971年生，辽宁省本溪市人，汉族，2002年苏州医学院毕业，硕士，副主任医师，主要从事生物材料方面的研究。 xy7224@sina.com
  • 基金资助:

    卫生部立项资助课题(WKZ-2000-1-17)。

Preparation and biological degradation of chitosan tube stent

Li Ya-xun1, Chen Gang2, Shi Wen-jun2   

  1. 1 Department of General Surgery, First Affiliated Hospital of Liaoning Medical University, Jinzhou  121001, Liaoning Province, China; 2 Department of Thoracic Surgery, Second Affiliated Hospital of Chinese Medical University, Shenyang  110003, Liaoning Province, China
  • Online:2010-07-16 Published:2010-07-16
  • About author:Li Ya-xun★, Master, Associate chief physician, Department of General Surgery, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, Liaoning Province, China xy7224@sina.com
  • Supported by:

    the Subject of Ministry of Health, No. WKZ-2000-1-17*

PDF

493

被引次数

7

摘要：

背景：作者课题组在进行肺组织瓣修补食管缺损实验中，发现硅胶支架和金属支架都不理想，都存在排斥反应和远期并发症，为寻找一种理想的生物型可自行降解支架，将壳聚糖制成管型支架，观察其在生物体内的相容性和降解性，为食管重建提供一种可降解支架。
目的：探讨壳聚糖管状支架的制备方法及其生物特性。
方法：利用乙酸溶液制备60 g/L的壳聚糖乙酸水溶胶，采用成膜方法制管后用NaOH脱下壳聚糖导管，取内径5 mm管，切成段，长度2 mm，消毒，并将壳聚糖管植入大鼠组织内，分别于不同时间段大体及光镜下观察其生物相容性及体内降解性。
结果与结论：壳聚糖导管光滑，韧性好，吸收水分变软，组织生物相容性好，随时间可被组织吸收降解。该方法提供了制备壳聚糖导管的一种新方法，并证实了其组织相容性和生物可降解性。

关键词: 壳聚糖, 生物高分子材料, 导管支架, 生物降解, 生物相容性

Abstract:

BACKGROUND: Our previous studies have demonstrated that rejection and long-term complication occur in repairing esophagus defects using ilica gel or metal stents. Chitosan stent is prepared in order to find an ideal biological degradation stent and to observe its in vivo compatibility and degradation.
OBJECTIVE: To explore the preparative method and biology characters of chitosan stents.
METHODS: Initially, acetic acid solution was added into chitosan to get 60 g/L chitosan acetic acid hydrosol, and then, the tube was prepared by membrane making way and the chitosan was took off in sodium hydroxide. The tube with 5-mm inside diameter was cut into a 2-mm length segment and implanted into rats. Gross observation and light microscope were used to observe compatibility and degradation of chitosan tube.
RESULTS AND CONCLUSION: The chitosan tube presented with smooth surface and good tenacity, which could be soften after absorbing water. The tube could be absorbed and degraded by tissues with time prolonged. It gives a new kind of way to prepare chitosan tube and approves the biological degradation.

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