中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (24): 4537-4540.doi: 10.3969/j.issn.1673-8225.2011.24.041

• 组织构建与生物活性因子 tissue construction and bioactive factors • 上一篇    下一篇

转化生长因子β1与骨生化指标和骨密度的关系

皮银珍1，廖二元2   

  1. 1长沙市第一医院内分泌科，湖南省长沙市  410006
    2中南大学湘雅二医院代谢内分泌研究所，湖南省长沙市  410011
  • 收稿日期:2010-12-08 修回日期:2011-01-10 出版日期:2011-06-11 发布日期:2011-06-11
  • 通讯作者: 廖二元，博士，教授，博士生导师。中南大学湘雅二医院代谢内分泌研究所，湖南省长沙市 410011
  • 作者简介:皮银珍★，女，1967年生，湖南省津市人，汉族，2004年中南大学毕业，硕士，副主任医师，主要从事代谢性骨病方面的研究。
  • 基金资助:

    卫生部临床学科重点项目(编号：2001035427)，课题名称：新一代骨质疏松生化标志物筛查和应用。

Relationship of transforming growth factor beta 1 with bone turnover markers and bone mineral density

Pi Yin-zhen1, Liao Er-yuan2   

  1. 1Department of Endocrinology, the First Hospital of Changsha, Changsha  410006, Hunan Province, China
    2Institute of Metabolism and Endocrinology, Second Xiangya Hospital of Central South University, Changsha  410011, Hunan Province, China
  • Received:2010-12-08 Revised:2011-01-10 Online:2011-06-11 Published:2011-06-11
  • Contact: Liao Er-yuan, Doctor, Professor, Doctoral supervisor, Institute of Metabolism and Endocrinology, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China eyliao1207@21.cn. com
  • About author:Pi Yin-zhen★, Master, Associate chief physician, Department of Endocrinology, the First Hospital of Changsha, Changsha 410006, Hunan Province, China yinzhenpi@126.com
  • Supported by:

    the Key Clinical Project of Chinese Ministry of Health, No. 2001035427*

PDF

323

摘要：

背景： 转化生长因子β1是一种重要的调节骨构塑的细胞因子，其是否能作为反应骨转换的敏感因子尚不清楚。
目的：探讨转化生长因子β1与骨形成、骨吸收指标，以及腰椎正位骨密度间的关系。
方法：实验共纳入来自长沙的健康妇女663名，年龄20~80岁。采用ELISA法测定空腹血清转化生长因子β1、骨特异性碱性磷酸酶和Ⅰ型胶原羧基末端肽的水平，同时应用双能X射线骨密度仪测定腰椎正位的骨密度。并分析转化生长因子β1与其他各指标的相关性。
结果与结论：检测结果显示30~39岁，40~49岁年龄段妇女的血清转化生长因子β1水平最高，转化生长因子β1水平与年龄呈负相关，与体质量指数无相关。校正体质量指数后发现，转化生长因子β1与骨特异性碱性磷酸酶和Ⅰ型胶原羧基末端肽负相关，校正体质量指数和年龄后血清转化生长因子β1水平与腰椎正位骨密度正相关。说明转化生长因子β1能动态地反映骨转换情况。

关键词:  , 转化生长因子, 骨形成, 骨吸收, 骨密度

Abstract:

BACKGROUND: Transforming growth factor-β1(TGF-β1) is an important cytokine in the regulation of bone remodeling. Whether it can be used as a sensitive marker to bone turnover is incompletely understood.
OBJECTIVE: To investigate the relationship of TGF-β1 with bone formation and resorption markers, and bone mineral density (BMD) at the anteroposterior lumbar spine.
METHODS: Totally 663 healthy women from Changsha were analyzed, aged 20-80 years. Levels of TGF-β1, serum bone alkaline phosphatase (sBAP) and serum C-terminal cross-linked telopeptides (sCTx) were measured by ELISA, at the same time, the BMD of anteroposterior lumbar spine was measured by dual-energy x-ray absorptiometry. The associations between TGF-β1 and other indexes were analyzed.  
RESULTS AND CONCLUSION: The TGF-β1 levels reached a peak in the 30-39 and 40-49 years groups, which had a negative correlation with age, but no correlation with body mass index (BMI). After corrected for BMI, TGF-β1 was negatively correlated to sBAP and sCTx, but was positively correlated with BMD of spine after correction of BMI or age. TGF-β1 can act as a sensitive cytokine to reflect the changes of bone turnover.

中图分类号: