中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (34): 6437-6440.doi: 10.3969/j.issn.1673-8225.2010.34.041

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

药物缓释体抗胶质瘤的效用分析

夏学巍   

  1. 桂林医学院附属医院神经外科，广西壮族自治区桂林市 541001
  • 出版日期:2010-08-20 发布日期:2010-08-20
  • 作者简介:夏学巍☆，男，1974年生，辽宁省沈阳市人，汉族，2006年中国协和医科大学北京协和医院毕业，博士，副主任医师，主要从事神经外科基础研究与临床工作。 xxw7456@gmail.com

Effectiveness analysis of controlled-release drug delivery system for treating glioma

Xia Xue-wei   

  1. Department of Neurosurgery, Affiliated Hospital of Guilin Medical College, Guilin   541001, Guangxi Zhuang Autonomous Region, China
  • Online:2010-08-20 Published:2010-08-20
  • About author:Xia Xue-wei☆, Doctor, Associate chief physician, Department of Neurosurgery, Affiliated Hospital of Guilin Medical College, Guilin 541001, Guangxi Zhuang Autonomous Region, China xxw7456@gmail.com

PDF

387

被引次数

5

摘要：

目的：对药物缓释系统抗胶质瘤中载体材料的类型、材料生物学特点及其应用进行了归纳总结。
方法：作者应用计算机检索PubMed(http://www.ncbi.nlm.nih.gov/PubMed)及CNKI数据库(www.cnki.net/index.htm)，在标题和摘要中以“聚乳酸，载体，间质内化疗”或“Polylactic acid, vector, interstitial chemotherapy”为检索词进行检索。选择文章与药物缓释体，聚乳酸，载体及其应用效果相关，同一领域文献则选择近期发表或发表在权威杂志文章。共纳入13篇文献。
结果：作为药物缓释体的载体应具备良好的生物相容性、高分子聚合物和降解产物均无毒，适当的物理机械性能及可成型性，具有可以调节的降解速度。目前间质内化疗治疗胶质瘤复发，即缓释控释给药系统，不需频繁给药，能在较长时间内维持体内有效的药物浓度，从而可以显著提高药效和降低毒副作用。与静脉化疗药物治疗相比，毒副作用少且疗效好。
结论：选择具有良好生物学特性的可降解高分子为载体的化疗缓释体，进行间质内化疗较静脉化疗有明显优势，极具开发潜能。

关键词: 药物缓释体, 聚乳酸, 载体, 胶质瘤, 间质内化疗

Abstract:

OBJECTIVE: To summarize the type, biological characteristics and applications of anti-glioma controlled-release drug delivery system vector materials.
METHODS: A computer search was performed in PubMed (http://www.ncbi.nlm.nih.gov/PubMed) and CNKI Database (www.cnki.net/index.htm) by screening “lactic acid, vector, interstitial chemotherapy” in Chinese and “Polylactic acid, vector, interstitial chemotherapy” in English as key words in the titles and abstracts. Articles related to controlled-release drug delivery system, polylactic acid, vector and its application effect were included, those in the same field preferred to the recently published literature or published in the authority journals. Thirteen articles were included.
RESULTS: The ideal vector of the delivery system should have good biocompatibility, nontoxic polymers and degradation products, suitable physico-mechanical properties and formability, controlled degradation rate. Currently interstitial chemotherapy of glioma recurrence, that is controlled-release drug delivery system, do not require frequent administration, it can maintain effective drug concentrations in vivo for a long period, thus significantly improving the drug efficacy and reducing toxicity. Compared with intravenous chemotherapy treatment, it has fewer side effects and better efficacy.
CONCLUSION: The biodegradable polymer with good biological characteristics serving as the vector of the controlled-release drug delivery system for interstitial chemotherapy has significant advantages and great development potential.

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