Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (12): 1931-1937.doi: 10.3969/j.issn.2095-4344.2015.12.024

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Basic fibroblast growth factor and fibrin glue in orthopedics

Li Qi, Li Jian   

  1. Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Revised:2015-02-17 Online:2015-03-19 Published:2015-03-19
  • Contact: Li Jian, Master, Professor, Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • About author:Li Qi, M.D., Attending physician, Department of Orthopedic Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81101393

Abstract:

BACKGROUND: Basic fibroblast growth factor can promote angiogenesis and connective tissue regeneration, but it can be degraded rapidly in vivo. Fibrin glue as a carrier can play a slow-release effect against the rapid degradation of basic fibroblast growth factor, so as to better play the biological role of basic fibroblast growth factor. But at present, the concrete application of them is still in the research stage.
OBJECTIVE: To review the research progress of the application of basic fibroblast growth factor and fibrin glue in orthopedics.
METHODS: The recent literature concerning the application of basic fibroblast growth factor and fibrin glue in orthopedics was extensively reviewed by the first author through a computer-based retrieval of CNKI and Medline databases (2000-2014).
RESULTS AND CONCLUSION: Finally 64 articles were included in result analysis. Basic fibroblast growth factor can promote wound healing and tissue repair with the fibrin glue used as a carrier, but most studies are still in the experimental stage and its clinical application needs further study.


中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程


全文链接:

Key words: Tissue Engineering, Ligaments, Fractures, Bone

CLC Number: