OBJECTIVE: To observe the promoting effect of semisynthetic extracellular matrix-like hydrogel containing hepatocyte growth factor on the repair of femoral neck defects in vivo.

METHODS: Twelve rabbits were taken to make bilateral femoral neck defect models. Based on autologous paired comparison, the left side was control side without treatment, and the right side served as experimental side undergoing implantation of semisynthetic extracellular matrix-like hydrogel containing hepatocyte growth factor.   

RESULTS AND CONCLUSION: Hematoxylin-eosin staining showed more uniform distribution of vessels in the defect area of the experimental side than the control side after 2 weeks; after 4 weeks, new bone trabeculae were full of the defect area of the experimental side, but bone trabeculae from inside to outside formed less in the control side; after 8 weeks, cortical bone formation appeared in the experimental side, with the reascularization of the bone marrow cavity that was filled with the bone marrow cells, while in the controlled side, thick calluses were still full of the defect area which blocking the bone marrow cavity. Mammography X-ray observations showed that at 8 weeks, it was difficult to distinguish the border between normal bone and new bone in the experimental side, but the border was still obvious in the controls side. It is confirmed that semisynthetic extracellular matrix-like hydrogel containing hepatocyte growth factor is beneficial to repairing femoral neck defects of rabbits.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

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