Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (18): 3380-3382.doi: 10.3969/j.issn.1673-8225.2012.18.031

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Relationship between proliferating cell nuclear antigen and intestinal development 

Tang Meng-qian, Liu Xue-hong   

  1. School of Medicine, Shaoxing University, Shaoxing  312000, Zhejiang Province, China
  • Received:2011-10-27 Revised:2011-11-15 Online:2012-04-29 Published:2012-04-29
  • Contact: Liu Xue-hong, Lecturer, School of Medicine, Shaoxing University, Shaoxing 312000, Zhejiang Province, China lxh6588@yahoo.com.cn
  • About author:Tang Meng-qian, School of Medicine, Shaoxing University, Shaoxing 312000, Zhejiang Province, China tmq627715@126.com
  • Supported by:

    the Science and Technology Innovation Program of College Students in Zhejiang Province, No. 2010r426033

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Abstract:

BACKGROUND: Embryonic development mechanism is hot spot in small intestine embryonic development and small intestine transplantation research.
OBJECTIVE: To review mechanism of cell proliferation in the small intestine and relationship between cell proliferation and clinical intestinal disease.
METHODS: VIP and Wanfang databases were retrieved by computer with the key words of “small intestine, proliferating cell nuclear antigen” in Chinese (1989-01/2011-08). At the same time, PubMed, Springer and e-book (full text) databases were retrieved with the key words of “small intestine, PCNA” in English (1989-01/2011-08). Totally 300 articles were retrieved, and finally 21 articles were included.
RESULTS AND CONCLUSION: With the biotechnological innovations and the deepening study of proliferating cell nuclear antigen (PCNA) in tissue and organ development of embryonic small intestine and intestinal disease, the relationship among PCNA, intestinal development and disease is illustrated gradually. Stage of embryonic development is the critical period of the development of small intestine, during the development of small intestine, cell proliferation and apoptosis is in a dynamic equilibrium which is precise regulated by a series of genes. Expression activity of PCNA can reflect cell proliferation activity.

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