Abstract:

BACKGROUND: At present, many types of drugs are used to prevent and treat immune rejection after liver transplantation, the new drugs are developed, and the immunosuppressive regimens are also various. But there are not uniform standards for them until now.
OBJECTIVE: To sum and evaluate the immunosuppressants which are used in the clinical treatment after liver transplantation and introduce several hot problems about immunosuppressive treatment in recent years.
METHODS: First author searched the literatures from CNKI database (2000/2011) and PubMed database (2000/2011). The key words were “Liver transplantation, Immunosuppression, Application, Side-effect, WithdrawaI” in Chinese and English. The application and research progress of immunosuppressant after liver transplantation, the choice of immunosuppressive regimens, the research about corticosteroid withdrawal and immunosuppressant withdrawal were summed up. A total of 158 articles were obtained and 45 articles were included accoding to the inclusion and exclusion criteria.
RESULTS AND CONCLUSION: The results show that a great variety of immunosuppressive drugs, which have significant side-effects, are used for liver transplantation presently; many new efficient immunodepressant, with low toxicity, are also being developed and had a wide prospect; the research about new immunosuppressive regimens, such as corticosteroid withdrawal and immunosuppressant withdrawal, has achieved some good clinical results under certain conditions, but their long-term efficacy and safety have not been confirmed. The life quality and survival rate of the liver transplanted patients can be greatly improved through the rational selection and use of immunosuppressant, the development of new drugs and exploring new immunosuppressive regimens.