Clinical assessment criteria of donor pancreas transplants for simultaneous pancreas-kidney transplantation

doi:10.3969/j.issn.2095-4344.2733

Abstract

Abstract:

BACKGROUND: Simultaneous pancreas-kidney transplantation is the main method for the treatment of end-stage diabetic nephropathy. The quality of donor pancreas is directly related to the surgical safety and long-term survival of the recipient. However, there is yet no unified standard for the evaluation of pancreatic-kidney transplantation in China.

OBJECTIVE: To summarize the assessment criteria of donor pancreas transplants base on 63 cases of donation after brain death.

METHODS: From September 2016 to November 2018, clinical data of potential pancreas donors after brain death, donor acquisition, and simultaneous pancreas-kidney transplantation were evaluated in the Second

Affiliated Hospital of Guangzhou Medical University in China. Pancreas and kidney transplants were from organ donation launched by organ procurement organizations, and the diagnoses of brain death were based on the Criteria for Determination of Brain Death in Adults. We rigorously evaluated and screened potential donors based on the pancreas donor criteria for simultaneous pancreas-kidney transplantation.

RESULTS AND CONCLUSION: A total of 168 potential pancreas donors after brain death were subjected to rigorous assessment and 63 donor pancreas transplants for simultaneous pancreas-kidney transplantation were successfully obtained. The time for cold ischemia was 145-320 minutes. Sixty-three transplant recipients were all operated with the ipsilateral simultaneous pancreas-kidney transplantation. The operation was successful in all the 63 patients. One patient needed to take oral antihyperglycemic drugs, and one patient had a demand for insulin therapy to control the blood glucose level in normal range. The levels of blood glucose in the other patients were normal with no need of oral antidiabetic drugs and insulin, and the outcome of treatment was satisfactory. To conclude, we provide a simple but effective way to assess pancreas allograft quality, improve the utilization of donor pancreas, and achieve favorable operation outcomes.

Key words: organ donation, donation after brain death, simultaneous pancreas-kidney transplantation, pancreas transplantation, donor pancreas assessment criteria

CLC Number:

Liu Luhao, Fang Jiali, Zhang Lei, Li Guanghui, Xu Lu, Lai Xingqiang, Xiong Yunyi, Chen Rongxin, Ma Junjie, Chen Zheng. Clinical assessment criteria of donor pancreas transplants for simultaneous pancreas-kidney transplantation[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(26): 4157-4161.

Figures/Tables 6

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