Mesenchymal stem cell transplantation for four kinds of rheumatic diseases: clinical analysis of 10-year data

doi:10.3969/j.issn.2095-4344.2014.14.021

Abstract

Abstract:

BACKGROUND: Mesenchymal stem cell is an important member of stem cell family, and it is increasingly used in the treatment of rheumatic diseases in recent years.
OBJECTIVE: To analyze the efficacy and safety of mesenchymal stem cell transplantation in patients with rheumatic disease in China.
METHODS: A computer-based search was conducted in Chinese Journal Full-text database and China Science and Technology Journal Database for relevant articles published from 2004 to 2013. Manual searching was also done. Key words were “mesenchymal stem cell”, “systemic lupus erythematosus”, “rheumatoid arthritis”, “myositis” and “systemic sclerosis” in Chinese.
RESULTS AND CONCLUSION: Twelve papers were selected and analyzed in this study. A total of 76 patients with rheumatic disease were reported in these 12 papers, including 46 (61%) cases of systemic lupus erythematosus, 21 (28%) of rheumatoid arthritis, 8 (11%) of polymyositis/dermatomyositis and 1 (1%) of systemic sclerosis. All of the 76 patients’ clinical symptoms and laboratory test results were improved after treatment and no adverse reactions or complications occur. During the follow-up, 7 (9%) of the 76 patients relapsed, including 1 death case. These findings indicate that mesenchymal stem cell transplantation in patients with rheumatic disease is efficient and safe; however, more case-control studies, cohort studies and clinical trials are required to confirm the result.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

全文链接：

Key words: mesenchymal stem cell, mesenchymal stem cell transplantation, rheumatic diseases, lupus erythematosus, systemic, arthritis, rheumatoid, polymyositis, dermatomyositis, scleroderma, systemic

CLC Number:

R318

Chen Huan-xue, Wang Xiao-fei. Mesenchymal stem cell transplantation for four kinds of rheumatic diseases: clinical analysis of 10-year data[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(14): 2263-2268.

Figures/Tables 4

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