Abstract:

BACKGROUND: Currently, studies on targeted and controlled release of gastric cancer drugs have obtained an obvious progress, but there are still some problems.
OBJECTIVE: To conclude the application status of gastric cancer drugs in targeted and controlled release manners in recent years.
METHODS: A computer search of VIP database was performed for articles about targeted and controlled release of gastric cancer drugs published between January 1998 and October 2010. The keywords were “gastric cancer, delayed release, target” in Chinese and English. Finally, 31 articles were included in result analysis.
RESULTS AND CONCLUSION: Currently, there are many studies concerning lymphatic-targeted chemotherapy of gastric cancer, and nano-carbon used in lymphatic targeted chemotherapy in gastric cancer has obtained initial success, which is expected to become the primary means of lymphatic targeted chemotherapy for gastric cancer. How to select a proper administration approach is needed to be further studied as well as how to combine different drugs via multi-approaches and regulate chemotherapy standards for gastric cancer and how to develop individualized treatment. Targeted and controlled release gastric cancer drugs are characterized as low toxicity, functional release and good lymphatic tendency, which are expected to inhibit primary tumor incidence and lymp node metastasis, shrink the tumor, increase resection size, reduce the recurrence and metastasis, so as to improve patients’ survival rate and quality of life.