Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (25): 4587-4590.doi: 10.3969/j.issn.1673-8225.2011.25.008

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Preparation and biocompatibility evaluation of composite scaffold material of polyvinyl alcohol/gelatin

Guo Tao1, Han Zhi2, Yang Tian-fu3, Li Yu-bao4, Yuan Tian-hong5, Xiao Jie1, Chen Yi-xin1   

  1. 1Department of Orthopedics, Guiyang 4th People’s Hospital, Guiyang  550002, Guizhou Province, China
    2Guiyang College of Traditional Chinese Medicine, Guiyang  550002, Guizhou Province, China
    3Department of Orthopedics, West China Hospital, Sichuan University, Chengdu  610041, Sichuan Province, China
    4Centre of Analysis and Determination, Sichuan University, Chengdu  610041, Sichuan Province, China
    5Guiyang Medical College, Guiyang  550004, Guizhou Province, China
  • Received:2011-03-03 Revised:2011-05-07 Online:2011-06-18 Published:2014-01-10
  • About author:Guo Tao☆, Doctor, Associate chief physician, Department of Orthopedics, Guiyang 4th People’s Hospital, Guiyang 550002, Guizhou Province, China guotao04b@sina.com

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Abstract:

BACKGROUND: The tissue engineered scaffolds prepared with gelatin as base have good biocompatibility and biodegradability, but low mechanical properties and difficulty to control degradation rate are their shortcomings.
OBJECTIVE: To prepare a new type of composite scaffold material of polyvinyl alcohol/gelatin and to evaluate the biocompatibility of composite scaffold.
METHODS: New type composite materials (polyvinyl alcohol/gelatin) were prepared by foaming method. The pore size and porosity, IR spectroscopy, mechanical performance and biocompatibility were detected by using scanning electron microscope, mechanical test and subcutaneous implantation test.
RESULTS AND CONCLUSION: Composite materials (polyvinyl alcohol/gelatin) were three-dimensional porous structure. The pore size was even, and the porosity was 61.8%. The water content rate of the composite materials was 44.6%. The tensile strength was (5.01±0.03) MPa, and the compressive strength was (1.47±0.36) MPa. The new type composite materials have been proved to have good biocompatibility and biomechanical properties.

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