Chinese Journal of Tissue Engineering Research ›› 2023, Vol. 27 ›› Issue (17): 2631-2636.doi: 10.12307/2023.195
Zhan Ying, Wu Xiaodan, Hao Shanhu
Received:
2022-03-01
Accepted:
2022-05-13
Online:
2023-06-18
Published:
2022-10-20
Contact:
Hao Shanhu, Master, Associate chief physician, General Hospital of Northern Theater Command, Shenyang 110016, Liaoning Province, China
About author:
Zhan Ying, Master, Technician in charge, General Hospital of Northern Theater Command, Shenyang 110016, Liaoning Province, China
CLC Number:
Zhan Ying, Wu Xiaodan, Hao Shanhu. Establishment of an animal model of radioactive 131I-induced hypothyroidism in rats[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(17): 2631-2636.
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2.1 实验动物数量分析 实验选用大鼠40只,分为5组, 12.95 MBq组在14周死亡1只鼠、15周死亡1只鼠,18.5 MBq组在12周死亡1只鼠、14周死亡2只鼠,4.625 MBq、9.25 MBq 组大鼠未出现死亡。 2.2 各组大鼠体征及体质量变化趋势比较 131Ⅰ 干预4周后9.25 MBq、12.95 MBq、18.5 MBq组大鼠均出现少动、饮水进食减少、反应淡漠等症状,而4.625 MBq组反应不明显。各剂量组与对照组相比,第4周体质量无明显差异(P > 0.05),第8,12,16周,9.25 MBq、12.95 MBq、18.5 MBq组大鼠 体质量与对照组相比明显下降(P < 0.05),而4.625 MBq组大鼠体质量与对照组相比各个时间点均无统计学变化, 见表1。"
2.4 各组大鼠血清丙氨酸氨基转移酶、门冬氨酸氨基转移酶、碱性磷酸酶、尿素氮、肌酐、尿酸水平比较 131Ⅰ 照射4周后,与对照组相比,4.625 MBq组和9.25 MBq组大鼠血清丙氨酸氨基转移酶、门冬氨酸氨基转移酶、碱性磷酸酶水平差异均无显著性意义(P > 0.05),12.95 MBq组和18.5 MBq组丙氨酸氨基转移酶、碱性磷酸酶水平升高(P < 0.05),门冬氨酸氨基转移酶水平无明显变化,见图1;与对照组相比, 4.625 MBq、9.25 MBq、12.95 MBq组大鼠血清尿素氮、肌酐、尿酸水平差异均无显著性意义(P > 0.05),18.5 MBq组尿素氮、肌酐水平升高(P < 0.05),尿酸水平无明显变化,见图2。"
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