Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (25): 4001-4008.doi: 10.12307/2021.011
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Lu Yuyun, Huang Mei, Shi Xinlei, Chen Baoyan
Received:
2020-05-09
Revised:
2020-05-14
Accepted:
2020-08-07
Online:
2021-09-08
Published:
2021-03-26
Contact:
Lu Yuyun, Department of Mammary Gland, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
About author:
Lu Yuyun, Attending physician, Department of Mammary Gland, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
Supported by:
CLC Number:
Lu Yuyun, Huang Mei, Shi Xinlei, Chen Baoyan. Bibliometric and visualization analysis of breast cancer stem cell literature from 2011 to 2020 based on Web of Science database[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(25): 4001-4008.
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2.2.4 支持乳腺癌干细胞研究的主要资助基金分析 基金分析显示,国家自然科学基金支持产出的文献数量最多,支持了222篇文献的发表,各占全球发表总数的21.915%。其次是NATIONAL INSTITUTES OF HEALTH NIH USA(美国国立卫生研究所)和UNITED STATES DEPARTMENT OF HEALTH HUMAN SERVICES(美国卫生公共服务部)都支持产出了182篇文献,占比17.966%,NIH NATIONAL CANCER INSTITUTE NCI(美国国家癌症研究所)支持产出的文献数量居全国第3,共有76篇文献发表,占比7.502%。见图9。"
2.3 有关乳腺癌干细胞文献的可视化分析 2.3.1 乳腺癌干细胞的研究方向分析 利用VOSviewer软件的关键词共现分析,文章以共同出现次数大于5次为纳入标准,在1 780个关键词中将91个关键词纳入研究,见图11。根据关键词共现图谱,文章将有关于乳腺癌干细胞的研究分为4大类:肿瘤学(红色)、基因遗传学(绿色)、乳腺癌干细胞应用于乳腺癌的治疗(蓝色)、分子生物学(黄色)。将上述4大研究方向细化,在肿瘤学中,出现次数较多的关键词有:三阴性乳腺癌、扩散、靶标、通路、抵制、药物抵抗、转移、姜黄素、顺铂、细胞凋亡、二甲双胍和细胞周期;在基因遗传学中,c-myc、stat3、bmi1、ezh2、nanog、自我吞噬和sox2为常出现的关键词;在乳腺癌干细胞应用于乳腺癌的治疗中,出现次数较多的关键词有:抗乳腺癌干细胞特性、新陈代谢、生物标志物、放射疗法、双硫仑、辐射及上皮细胞-间充质转化;在分子生物学中,beta-catenin、DNA-甲基化、cd24、e-cadherin和cd44为出现次数较多的关键词。结合表1中被引频次top10文献的相关信息分析,文章发现:有关化疗与二甲双胍的联合治疗、抗血管生成剂的靶向治疗、sox2、ezh2及nanog基因涉及到的调节机制的探索、上皮-间充质干细胞转化及CD44和CD24分子标志物的研究是重点研究方向。 "
2.3.2 乳腺癌干细胞发展趋势分析 运用VOSviewer的发展趋势分析功能,文章整理出了关键词出现的先后顺序,见图12,图中右下角按颜色从紫-蓝-青-绿-黄-橙-红排列的刻度线代表了时间的先后顺序,圆圈的颜色越接近紫色说明关键词出现在研究早期,越接近红色则说明越接近如今的研究热点。基因遗传学、分子生物学、肿瘤学及乳腺癌干细胞应用于乳腺癌的治疗是该领域发展趋势变化。出现时间最接近当今的关键词是核转录因子κB(NF-κB)通路和抗乳腺癌干细胞特性(stemness)。根据表2,3中的相关文献信息,文章推断:与NF-κB通路相关的HRG/ErbB3信号、紫檀芪和双硫仑是研究热点;与乳腺癌干细胞特性相关的上皮/间充质杂质基因、 miR34a-NOTCH1轴和LINC00511/miR-185-3p/E2F1/Nanog轴是重点研究内容。"
2.4 乳腺癌干细胞的合著分析 2.4.1 作者合著分析 以大于5篇为纳入标准,6 545名作者中共有96名作者被纳入研究范围。链接强度排名前5的作者依次是Mao Jun(大连医科大学)(链接强度=65),Li Lianhong(大连医科大学)和Lu Ying(大连医科大学)(链接强度=56),Fan Shujun(大连医科大学)、Liu Suling(复旦大学)、Song Bo(大连医科大学)、Yu Xiaotang(大连医科大学)(链接强度=55),Wicha Max s(密歇根大学)(链接强度=54),Ginestier Christophe(艾克斯-马赛大学)(链接强度=48),见图13。"
2.4.2 机构合著分析 以大于5篇为纳入标准,在1 302个机构中最终有108个机构符合纳入标准。在乳腺癌干细胞领域合著较多的机构见图14,其中进入前5的依次是中山大学(链接强度= 47)、复旦大学(链接强度=43)、大连医科大学(链接强度=31)、德克萨斯大学德森癌症研究中心(链接强度=30)和密歇根大学(链接强度=29)。 2.4.3 国家/地区合著分析 以大于5篇为纳入标准,在60个国家/地区中有31个国家/地区进入国家/地区合著分析中。链接强度前5名依次为美国(链接强度= 197)、中国(链接强度=109)、英国(链接强度=60)、意大利(链接强度=33)和中国台湾(链接强度=30)。 "
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