Molecular mechanism of icariin in the treatment of bone nonunion

doi:10.3969/j.issn.2095-4344.2718

Chinese Journal of Tissue Engineering Research ›› 2020, Vol. 24 ›› Issue (26): 4218-4223.doi: 10.3969/j.issn.2095-4344.2718

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Molecular mechanism of icariin in the treatment of bone nonunion

Yu Shaoyong¹, Zhang Xiaoyun², Chen Yueping², Liu Jianhang³

¹Master Hall of Traditional Chinese Medicine, ²Department of Orthopedic Trauma and Hand Surgery, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China; ³Beihai Traditional Chinese Medicine Hospital (Beihai Hospital Affiliated to Guangxi University of Chinese Medicine), Beihai 536000, Guangxi Zhuang Autonomous Region, China

Received:2019-08-27 Revised:2019-08-30 Accepted:2019-10-09 Online:2020-09-18 Published:2020-09-03
Contact: Zhang Xiaoyun, Master, Attending physician, Department of Orthopedic Trauma and Hand Surgery, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
About author:Yu Shaoyong, Master candidate, Master Hall of Traditional Chinese Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, Guangxi Zhuang Autonomous Region, China
Supported by:
the National Natural Science Foundation of China, No. 81760796 and 81960803 ; the Project of Guangxi Administration of Traditional Chinese Medicine, No. GZZC2019096; the Project of Guangxi Health Committee, No. Z20190345; the Middle-aged and Young Teachers’ Basic Ability Improvement Project of Guangxi Zhuang Autonomous Region, No. 2019KY0352; the Natural Science Foundation of Guangxi University of Chinese Medicine, No. 2019QN027; First-Class Subject Construction Open Project of Guangxi University of Chinese Medicine, No. 2019XK029

Abstract

Abstract:

BACKGROUND: Nonunion is a common clinical complication in orthopedics, which seriously impacts the physical and mental health and quality of life of patients. In recent years, a large number of studies have found that icariin plays a significant role in promoting fracture healing and treating bone defects. Bone nonunion and fracture healing coexist, and the research on the mechanism of fracture healing actually focuses on the treatment of bone nonunion.

OBJECTIVE: To review the research progress in the molecular mechanism of icariin in the treatment of bone nonunion.

METHODS: The first author used “icariin, bone nonunion, bone marrow mesenchymal stem cells, periosteal cell, osteoblasts, osteoclast” as key words in English and Chinese to search PubMed, CNKI, WanFang and VIP databases. A total of 542 articles were retrieved and screened manually according to the selection criteria and exclusion criteria. Finally, 44 articles were included for result analysis.

RESULTS AND CONCLUSION: Icariin can effectively promote fracture healing and treat bone nonunion by promoting the proliferation and differentiation of bone marrow mesenchymal stem cells and periosteal cells, promoting the proliferation and maturation of osteoblasts and inhibiting the osteoclast effect of osteoclasts. However, most of the experiments are still in the basic experimental research, and there is still a need for a large number of clinical studies as well as studies on related proteins and genes, to provide a new idea for the clinical use of Chinese herbs in the treatment of bone nonunion.

Key words: icariin, bone nonunion, fracture nonunion, bone defect, bone marrow mesenchymal stem cell, periosteal cell, osteoblast, osteoclast

CLC Number:

Yu Shaoyong, Zhang Xiaoyun, Chen Yueping, Liu Jianhang.

Molecular mechanism of icariin in the treatment of bone nonunion [J]. Chinese Journal of Tissue Engineering Research, 2020, 24(26): 4218-4223.

Figures/Tables 2

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Molecular mechanism of icariin in the treatment of bone nonunion

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