Study on mechanism of radix angelicae pubescentis in the treatment of osteoarthritis based on network pharmacology

doi:10.3969/j.issn.2095-4344.1060

Abstract

Abstract:

BACKGROUND: Angelicae pubescentis radix has been extensively applied in the treatment of osteoarthritis, but the underlying molecular mechanism remains unclear.
OBJECTIVE: To construct the active ingredient-target network through screening the chemical ingredients of angelicae pubescentis radix based on network pharmacology, and to explore the mechanism underlying the treatment of osteoarthritis.
METHODS: The main active ingredients of angelicae pubescentis radix were obtained by Traditional Chinese Medicine Systems Pharmacology Database and the targets of osteoarthritis were retrieved from OMIM, TTD, pharmGKB Database. The “active ingredient-target” and “target-related diseases” network were constructed by the Cytoscape3.6.1 software. The biological functions and related pathways were analyzed by GlueGO and KEGG plugin.
RESULTS AND CONCLUSION: A total of 8 active ingredients and 52 targets were screened in angelicae pubescentis radix from Traditional Chinese Medicine Systems Pharmacology Database. A total of 120 target-related to osteoarthritis were got from OMIM, TTD, pharmGKB Database. Twenty common targets were found in “active ingredient-target” and “target-related diseases” network. The analysis of GlueGO and KEGG showed the radix angelicae pubescentis not only involved in the biological functions of lipolysis, calcium transport, T cell stabilization, embryonic cell differentiation, and cell apoptosis, but also modulated the signaling pathways of calcium, tumor necrosis factor, oxytocin, cyclic adenosine monophosphate, mitogen-activated protein kinase, and apoptosis. This study reveals that the potential active ingredients and possible mechanism of angelicae pubescentis radix for osteoarthritis, provides a basis for the development of new drugs in the treatment of osteoarthritis.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Heracleum, Computational Biology, Tissue Engineering

CLC Number:

R453
R285

Cheng Xiaoping1, Zheng Wenwei2, Ni Guoxin1. Study on mechanism of radix angelicae pubescentis in the treatment of osteoarthritis based on network pharmacology[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(11): 1641-1646.

Figures/Tables 5

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