Effect of high-viscosity cement dispersion on the treatment of osteoporotic vertebral compression fracture in elderly women

doi:10.3969/j.issn.2095-4344.1558

Abstract

Abstract:

BACKGROUND: High-viscosity bone cement is modified on the basis of traditional polymethylmethacrylate with the long injection time, high-viscosity and low polymerized temperature feature and further improves the safety of percutaneous vertebroplasty.

OBJECTIVE: To analyze the effect of high-viscosity bone cement dispersion on the clinical outcomes in elderly female patients with osteoporotic vertebral compression fracture who have undergone percutaneous vertebroplasty.

METHODS: Totally 120 elderly female patients with primary single-segmental osteoporotic vertebral compression fracture aged from 53 to 83 years were included, and percutaneous vertebroplasty with high-viscosity bone cement was performed in all the enrolled patients. The patients were assigned into two groups according to the bone cement dispersion shown on the lateral X-ray film. The bone cement dispersed to both endplates in the fractured vertebral bodyof 54 patients, who were marked as group A, and the other 66 patients were classified as group B. The group A patients were further divided into two subgroups in term of CT cross-sectional image, and the patients with the bone cement dispersing to the bilateral pedicles were taken as degree I (25 patients) and the others were termed as degree II (29 patients). All patients were followed up for more than 6 months, and the recovery rate of anterior height of the vertebra, local kyphosis angle improvement rate, visual analog scale scores and Oswestry dysfunction index score at the last follow-up were compared among groups.

RESULTS AND CONCLUSION: (1) The recovery rate of anterior height of the vertebra and local kyphosis angle improvement rate in group A were better than those in group B at the last follow-up (P < 0.05). (2) The visual analog scale scores and Oswestry dysfunction index scores in both A and B groups were significantly improved at the last follow-up compared to the baseline data (P < 0.05), but there was no significant difference between the two groups (P > 0.05). (3) The subgroups of degree I and II showed no significant difference in the recovery rate of anterior height of the vertebra and local kyphosis angle improvement rate at the last follow-up (P > 0.05). (4) There were nine patients with bone cement leakage, four patients with postoperative fever, two patients with low blood pressure in group A and eight patients with bone cement leakage, six patients with postoperative fever, two patients with high blood pressure, one patient with superficial skin infection in group B, but there was no significant difference in the postoperative complications between the two groups (P > 0.05). All the results suggest that percutaneous vertebroplasty with high-viscosity bone cement has positive efficacy in treating elderly women with single-segmental osteoporotic vertebral compression fracture. The better dispersion of bone cement in the fractured vertebrae indicates the better clinical effects. However, high-viscosity bone cement should be injected in an appropriate amount, as excessive dispersion will increase the risk of leakage.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Osteoporotic Fractures, Vertebroplasty, Tissue Engineering

CLC Number:

R459.9

Chen Cheng, Zhang Jiyun, Hao Jie, Wu Gang, Zhang Feng, Chen Xiaoqing. Effect of high-viscosity cement dispersion on the treatment of osteoporotic vertebral compression fracture in elderly women[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(6): 827-832.

Figures/Tables 7

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