Structural allogeneic freeze-dried bone bone for treatment of lumbar tuberculosis

doi:10.3969/j.issn.2095-4344.0678

Abstract

Abstract:

BACKGROUND: Increasing attentions have been paid to allogeneic freeze-dried bone, but it is uncertain whether it can substitute the autologous bone in the treatment of lumbar tuberculosis.

OBJECTIVE: To retrospectively analyze the therapeutic efficacy of structural allogeneic freeze-dried bone in the treatment of lumbar tuberculosis.

METHODS: 198 patients with lumbar tuberculosis scheduled for surgical treatment were selected, including 105 males and 93 females, 16-80 years of age. There were 168 cases of single-segment infection, 30 cases involving 2 segments and more than 2 infections, and 24 cases of obvious lumbar deformity. 129 of the 198 patients underwent anterior lumbar interbody fusion and internal fixation, 52 cases underwent simple posterior lumbar interbody fusion and internal fixation, and 17 cases underwent anterior and posterior lumbar interbody fusion and internal fixation. Structural allogeneic freeze-dried bone was used as the graft material. The postoperative neurological function, pain score, deformity correction, degree of bone fusion, fusion rate and complications were analyzed.

RESULTS AND CONCLUSION: All the patients were followed up for (30±11) years. At the final follow-up, C-reactive protein expression (P < 0.05), Japanese Orthopaedic Association score, Cobb angle (P < 0.05) and neurologic function were significantly improved compared with the preoperative data. The time for bone fusion was (9.3±2.2) months as assessed by X-ray and (12.7±3.1) months as assessed by CT. Bridwell grade I patients underwent postoperative CT examination, and trabecular bone formation was implemented in 141 cases, with the positive rate of 76%. Two patients had fractures of the bone graft within 6 postoperative months and six patients had recurrent tuberculosis, two of whom had sinus formation. All these findings indicate that on the basis of systemic anti-tuberculosis drugs, it is safe and feasible to treat lumbar tuberculosis with allogeneic freeze-dried bone.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Bone Transplantation, Tuberculosis, Spinal, Spinal Fusion, Tissue Engineering

CLC Number:

R318

Wang Pengbo, Sheng Weibin, Wang Bingchao, Cao Rui, Xu Tao, Pulati Maimaiti. Structural allogeneic freeze-dried bone bone for treatment of lumbar tuberculosis[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(34): 5439-5444.

Figures/Tables 5

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