Mesenchymal stem cells for cartilage repair in osteoarthritis

doi:10.3969/j.issn.2095-4344.0673

Abstract

Abstract:

BACKGROUND: The degeneration of articular cartilage represents an ongoing challenge at the clinical and basic levels. Considering the restricted intrinsic capacity of resident chondrocytes to regenerate post injury, stem cell-based therapies have been proposed as a novel therapeutic approach for cartilage repair. Mesenchymal stem cells are pluripotent and immunosuppressive, which have become the first choice for tissue engineering research.
OBJECTIVE: To summarize the application of mesenchymal stem cells derived from different tissues in cartilage repair in recent years.
METHODS: With “mesenchymal stem cells, cartilage damage repair, osteoarthritis” as retrieval words, we searched relevant articles regarding mesenchymal stem cells for cartilage repair in PubMed, Web of Science and CNKI. Initially 168 articles were retrieved, and 59 eligible articles (57 in English and 2 in Chinese) were included in final analysis.
RESULTS AND CONCLUSION: Mesenchymal stem cells with self-renewal ability can differentiate into a variety of mesodermal lineage cells, such as osteoblasts, chondrocytes, adipocytes, cardiomyocytes and vascular cells. The immunomodulatory and regenerative capacity of mesenchymal stem cells can regulate the imbalance of anabolism and catabolism in the osteoarthritic joint. Although a large number of mesenchymal stem cells have been used for cartilage repair in clinical practice, the mechanism underlying cartilage repair with mesenchymal stem cells is still unclear. Moreover, the therapeutic effect of mesenchymal stem cells is determined by cell sources, the number of transplanted cells and the way of injection. All of these problems need further explorations.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Osteoarthritis, Cell Transplantation, Review, Tissue Engineering

CLC Number:

R394.2

Zhang Shuang, Liu Shi, Wang Yu-feng, Lü Chan, Li Bao-ling, Wang Ping, Cong Jun, Zhu Zhi-qiang. Mesenchymal stem cells for cartilage repair in osteoarthritis[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(33): 5379-5385.

Figures/Tables 1

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