Design of a novel two-segment adjustable nano-hydroxyapatite/polyamide 66 artificial prosthesis based on Mimics measurements of CT scan data

doi:10.3969/j.issn.2095-4344.0942

Abstract

Abstract:

BACKGROUND: Previous studies have shown that commonly used prostheses for spinal repair are prone to have stress shielding effects (nonunion and local bone resorption) due to their limited high elastic modulus and limited contact areas, which can lead to the failure of internal fixation over time.

OBJECTIVE: To design a novel two-segment adjustable artificial vertebral body through the measurement of CT scan data of the vertebral body using Mimics software.

METHODS: Sixty young and middle-aged male patients with lumbar CT scan data were included. Mimics software was used to extract the skeleton contour of L_1-3 vertebrae and to measure the vertebral body height and the transverse diameter of the upper and lower end plates, sagittal diameter, sagittal and coronal concave angles. Based on the measured data, a new type of artificial vertebral body adjustably and anatomically fitting the vertebral endplate was designed.

RESULTS AND CONCLUSION: There was no significant difference in the L_1-3 height and sagittal diameter of the upper and lower endplates, and sagittal concave angle among all the cases. The transverse diameter of the upper endplate was significantly less than that of the lower endplate in the same vertebra (P < 0.05). A significant difference in the sagittal concave angle was also found (P < 0.05). Based on the measured vertebral height, sagittal diameter of the endplate and sagittal concave angle, a novel artificial vertebral body with adjustable height was designed. The new product made of nano-hydroxyapatite/polyamide 66 was composed of a top cover and a base. The height of the designed vertebral body could be controlled by bone cement injection via the side hole on the base. And it could be tightly integrated with the upper and lower endplates of the adjacent vertebral body, which is beneficial to promote the osseointegration. In conclusion, the two-segment adjustable artificial vertebral body has the advantages of reasonable design and convenient operation.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Tissue Engineering, Biocompatible Materials, Lumbar Vertebrae

CLC Number:

R318

Chen Guang-hui, Cheng Li, Wang Jian, Huang Quan, Bai Guang-jian, Yin Meng-chen, Wei Hai-feng, Yang Cheng, Xiao Jian-ru, Liu Tie-long. Design of a novel two-segment adjustable nano-hydroxyapatite/polyamide 66 artificial prosthesis based on Mimics measurements of CT scan data[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(26): 4133-4138.

Figures/Tables 3

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