Effects of the combination of running and Eucommia ulmoides extract on the bone mineral density and antioxidant capacity in ovariectomized rats

doi:10.3969/j.issn.2095-4344.0267

Abstract

Abstract:

BACKGROUND: Exercise has been shown to increase bone mineral density (BMD) and improve body composition. Nevertheless, anti-oxidant capacity in postmenopausal women is significantly reduced, and it is crucial to prevent exercise-induced oxidative damage. Eucommia ulmoides has the abilities of increasing BMD and antioxidant capacity, so the combination of exercise and Eucommia ulmoides may be helpful to increase BMD and reduce oxidative damage in postmenopausal women.
OBJECTIVE: To investigate the effects of the combination of running and Eucommia ulmoides extract on the BMD, serum level of estrogen, bone metabolism and antioxidant capacity in ovariectomized rats.
METHODS: After the rats were allowed to acclimate for 1 week, the rats were randomly divided into two groups: ovariectomized and sham operation groups. The rats were recovered for 4 weeks, and the ovariectomized rats were randomly divided into model, Eucommia ulmoides and combination (Eucommia ulmoides and running) groups. The intervention time was 12 weeks. The 24-hour urine was recorded. All rats underwent exhaustive exercise on the following day and the blood samples from the abdominal cavity were collected. The oxidative indexes (serum levels of creatine kinase, lactate dehydrogenase, malondialdehyde, and superoxide dismutase, and glutathione peroxidase activity), bone metabolism indexes (serum levels of osteocalcin, alkaline phosphatase, creatine kinase, calcium and phosphorus, and urine levels of deoxypyridinoline, calcium and phosphorus), body mass, serum level of estradiol and femoral BMD were recorded.
RESULTS AND CONCLUSION: After 12 weeks of intervention, the body mass, levels of malondialdehyde, calcium, alkaline phosphatase and phosphorus in the Eucommia ulmoides and combination groups were significantly lower than those in the model group (P < 0.05). The serum level of estradiol and femoral BMD were significantly higher than those in the model group (P < 0.05). The indexes in the combination group all were superior to the Eucommia ulmoides and exercise groups (P > 0.05). These findings suggest that long-term running combined with Eucommia ulmoides extract or simple Eucommia ulmoides extract can significantly increase BMD, serum level of estrogen in ovariectomized rats, and can promote bone metabolism balance, reduce bone turnover rate and weight gain caused by ovarian dysfunction, thus maintaining bone mass and preventing osteoporosis.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Osteoporosis, Postmenopausal, Eucommiaceae, Running, Bone Density, Tissue Engineering

CLC Number:

R318

Cheng Lin. Effects of the combination of running and Eucommia ulmoides extract on the bone mineral density and antioxidant capacity in ovariectomized rats[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(24): 3837-3842.

Figures/Tables 2

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