Jaw bone and periodontal capillary casting in a Wistar rat model of occlusal trauma

doi:10.3969/j.issn.2095-4344.2016.49.015

Abstract

Abstract:

BACKGROUND: Occlusal trauma, a key factor of occurrence and development of periodontal diseases, has gradually become a hot spot of basic and clinical research.
OBJECTIVE: To explore the effect of occlusal trauma on jaw bone and periodontal capillaries.
METHODS: Forty-eight Wistar rats were enrolled and six rats were randomly selected as control group given anesthesia only. The photo-curing material was set at the 1 mm high of right mandibular molar area in 42 rats to simulate early contact inducing occlusal trauma. Periodontal capillary casting was conducted at 3 days, 1, 2, 3, 4, 6 and 8 weeks after modeling (6 rats per time point); the part of the jaw including teeth and periodontal tissues were isolated, and the casting specimens were observed by scanning electron microscope.
RESULTS AND CONCLUSION: At 3 days and 1 week after modeling, overt inflammatory reaction, slight reduction of vascular networks, and tortuous and thinner capillaries could be found, and alveolar bones had not been absorbed obviously. At 2, 3, and 4 weeks, the alveolar bones were absorbed gradually, and the capillary diameter and density were decreased markedly becoming more tortuous. The jaw bone absorption remained stable with increased capillaries at 6 weeks. Up to 8 weeks, abundant thinner capillaries appeared. These findings suggest that occlusal trauma will give rise to the morphological changes of periodontal capillaries.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

Key words: Rats, Wistar, Mandible, Capillaries, Periodontium

CLC Number:

R318

Bi Zhen-yu, Liu Yang, Wu Bin, Xie Chun, Yang Yu-chao, Ouyang Jun. Jaw bone and periodontal capillary casting in a Wistar rat model of occlusal trauma[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(49): 7397-7403.

Figures/Tables 3

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