Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (49): 7397-7403.doi: 10.3969/j.issn.2095-4344.2016.49.015

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Jaw bone and periodontal capillary casting in a Wistar rat model of occlusal trauma

Bi Zhen-yu1, Liu Yang2, Wu Bin2, Xie Chun2, Yang Yu-chao1, Ouyang Jun1   

  1. 1Department of Anatomy of Southern Medical University, Medical Biomechanics Key Laboratory of Guangdong Province, Guangzhou 510515, Guangdong Province, China; 2Department of Stamatology, People’s Hospital of Longhua New District of Shenzhen, Shenzhen 518109, Guangdong Province, China
  • Received:2016-09-03 Online:2016-11-30 Published:2016-11-30
  • Contact: Ouyang Jun, M.D., Professor, Doctoral supervisor, Department of Anatomy of Southern Medical University, Medical Biomechanics Key Laboratory of Guangdong Province, Guangzhou 510515, Guangdong Province, China
  • About author:Bi Zhen-yu, M.D., Lecturer, Department of Anatomy of Southern Medical University, Medical Biomechanics Key Laboratory of Guangdong Province, Guangzhou 510515, Guangdong Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 31170903; the Project of Health and Family Planning Commission of Shenzhen, No. 201506088

Abstract:

BACKGROUND: Occlusal trauma, a key factor of occurrence and development of periodontal diseases, has gradually become a hot spot of basic and clinical research.
OBJECTIVE: To explore the effect of occlusal trauma on jaw bone and periodontal capillaries.
METHODS: Forty-eight Wistar rats were enrolled and six rats were randomly selected as control group given anesthesia only. The photo-curing material was set at the 1 mm high of right mandibular molar area in 42 rats to simulate early contact inducing occlusal trauma. Periodontal capillary casting was conducted at 3 days, 1, 2, 3, 4, 6 and 8 weeks after modeling (6 rats per time point); the part of the jaw including teeth and periodontal tissues were isolated, and the casting specimens were observed by scanning electron microscope.
RESULTS AND CONCLUSION: At 3 days and 1 week after modeling, overt inflammatory reaction, slight reduction of vascular networks, and tortuous and thinner capillaries could be found, and alveolar bones had not been absorbed obviously. At 2, 3, and 4 weeks, the alveolar bones were absorbed gradually, and the capillary diameter and density were decreased markedly becoming more tortuous. The jaw bone absorption remained stable with increased capillaries at 6 weeks. Up to 8 weeks, abundant thinner capillaries appeared. These findings suggest that occlusal trauma will give rise to the morphological changes of periodontal capillaries.

中国组织工程研究杂志出版内容重点:肾移植肝移植移植;心脏移植;组织移植;皮肤移植;皮瓣移植;血管移植;器官移植组织工程

Key words: Rats, Wistar, Mandible, Capillaries, Periodontium

CLC Number: