Biocompatibility of different hemodialysis membrane materials in the treatment of severe acute pancreatitis

doi:10.3969/j.issn.2095-4344.2016.47.016

Abstract

Abstract:

BACKGROUND: In the clinical treatment of severe acute pancreatitis, there are different dialysis membrane materials. But the differences among these dialysis membrane materials are unclear.
OBJECTIVE: To compare the biocompatibility of polysulfone and cellulose acetate dialysis membranes.
METHODS: Totally 100 severe acute pancreatitis patients were included, including 51 males and 49 females, aged 34 to 81 years, and all were subjected to hemodialysis treatment (5 hours once, three times per week). Polysulfone membrane was used in 50 cases, and cellulose acetate dialysis membrane used in the other 50 cases. After 3 months of follow-up, the time of recovery from abdominal pain and abdominal distension, the time of blood amylase returning to normal levels, therapeutic efficacy and level of inflammatory factors were compared between two groups.
RESULTS AND CONCLUSION: There were no differences in the time of recovery from abdominal pain and abdominal distension, the time of blood amylase returning to normal levels, and therapeutic efficacy between the two groups. The levels of interleukin-6, C-reactive protein and tumor necrosis factor alpha in the two groups were significantly lower than those before hemodialysis treatment (P < 0.05), but there was no significant difference between the two groups. Results show that both polysulfone and cellulose acetate membranes used in hemodialysis treatment of severe acute pancreatitis have good biocompatibility.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Renal Dialysis, Pancreatitis, Tissue Engineering

CLC Number:

R318

Jiang Qi-dong, Wu Chang-xue. Biocompatibility of different hemodialysis membrane materials in the treatment of severe acute pancreatitis[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(47): 7106-7111.

Figures/Tables 4

References

[1]罗洋,卞维静.外周血单个核细胞凋亡评价血液透析膜生物相容性的实验研究[J].中国血液净化, 2008,7(4): 195-197.
[2]陈波,周青山,张静静,等.重症胰腺炎中血液透析膜的应用价值[J].中国医药导报,2013,10(28):20-22,33.
[3]卞书森,张福港,李晓东,等.血液透析膜的生物相容性研究进展[J].中国血液净化,2006,5(4):205-207.
[4]谢红浪,季大玺.不同透析膜的生物特性及临床应用[J].肾脏病与透析肾移植杂志,2004,13(4):374-377.
[5]张伟明.REXEED<'TM>系列聚砜膜高通量透析器性能评价的临床和实验研究[D].上海交通大学,2008.
[6]曹宁.肾功能衰竭患者采用不同血液透析膜材料的生物相容性对比分析[J].中国组织工程研究, 2012,16(25): 4727-4734.
[7]陈昕丽.透析膜的生物相容性对血清细胞因子的影响[J].中国血液净化,2004,3(3):141-143.
[8]Wald R, Shariff SZ, Adhikari NKJ, et al. The Association Between Renal Replacement Therapy Modality and Long-Term Outcomes Among Critically HI Adults With Acute Kidney Injury: A Retrospective Cohort Study. Crit Care Med.2014;42(4):868-877.
[9]王文,王宝仁,孙特,等.不同类型透析膜对维持性血液透析患者血清C-反应蛋白水平变化的影响[J].武警医学, 2004,15(12):891-893.
[10]田津生,张怡静.不同透析膜对血透患者血清C反应蛋白、白细胞介素-6、白细胞介素-8和白蛋白的影响[J].临床内科杂志,2012,29(1):40-42.
[11]潘碧霞,刘国辉,叶爱玲,等.不同材料血液透析膜的生物相容性及溶质清除能力的比较研究[J].中国医药指南, 2014, 12(21):97-99.
[12]Sikder J, Pereira C, Palchoudhury S, et al. Synthesis and characterization of cellulose acetate-polysulfone blend microfiltration membrane for separation of microbial cells from lactic acid fermentation broth. Desalination. 2009;249(2):802-808.
[13]石磊.不同透析膜材料在维持性血液透析过程中的生物相容性[J].中国组织工程研究与临床康复, 2010,14(34): 6453-6456.
[14]杨立峰,柯军,颜林,等.血液透析器的生物相容性研究及其临床应用现状[J].临床医学工程,2012,19(2):320-322.
[15]李远,赵战云,郭冀鲁,等.不同透析膜对维持性血液透析患者血清C-反应蛋白水平的影响[J].潍坊医学院学报, 2010, 32(6):439-441.
[16]于金刚,蒋新宇,焦飞鹏,等.血液透析膜的应用及其改性研究进展[J].科技导报,2013,31(5):98-105.
[17]Okita Y, Okahisa T, Sogabe M, et al. Low-volume continuous hemodiafiltration with nafamostat mesilate increases trypsin clearance without decreasing plasma trypsin concentration in severe acute pancreatitis. ASAIO J.2007;53(2):207-212.
[18]郭杰峰,梁静.不同维生素C使用方法下醋酸纤维膜透析器生物相容性的研究[J].中外健康文摘, 2014,10(7): 159-160.
[19]郑斌,张萍,何强,等.不同纯度的透析液对维持性血液透析患者微炎症状态的影响[J].浙江医学, 2012,37(7): 538-539.
[20]于黔,赵素云,蒋文勇,等.不同透析膜和不同血液净化方式对血液透析患者炎症介质的影响[J].临床肾脏病杂志, 2011,11(3):116-116.
[21]郭增革.纤维素/聚醚砜共混中空纤维透析膜的制备与性能研究[D].天津工业大学, 2012.
[22]王艳璇.低通量聚砜膜进行血液透析对患者血清IL-1β、C反应蛋白、补体C3、C4及中性粒细胞、单核细胞、血小板的影响[D].中国医科大学,2010.
[23]刘俊英.血液透析膜的生物相容性与透析并发症[J].中国组织工程研究与临床康复,2009,13(3):557-560.
[24]孟娟.血液透析中血流动力学与透析膜生物相容性对血管内皮细胞的影响[D].首都医科大学,2007.
[25]Kurita R, Yabumoto N, Niwa O, et al.Miniaturized one-chip electrochemical sensing device integrated with a dialysis membrane and double thin-layer flow channels for measuring blood samples. Biosensors Bioelectron 2006;21(8):1649-1653.
[26]钟一红,徐元钊,丁小强,等.血浆白细胞介素8水平对透析膜生物相容性的评价[J].复旦学报(医学版), 2002,29(2): 91-93,97.
[27]刘静,丰玲,张东亮,等.四种不同膜材料透析器生物相容性的临床研究[J].中华肾脏病杂志,2011,27(4):253-258.
[28]Ishihara K, Miyazaki H, Kurosaki T, et al.Improvement of blood compatibility on cellulose dialysis membrane. III. Synthesis and performance of water-soluble cellulose grafted with phospholipid polymer as coating material on cellulose dialysis membrane. J Biomed Mater Res B.1995;29(2):181-188.
[29]Yamamoto K, Kobayashi K, Endo K, et al. Hollow-fiber blood-dialysis membranes: superoxide generation, permeation, and dismutation measured by chemiluminescence. J Artif Organs. 2005;8(4):257-262.
[30]刘静.不同膜材料透析器生物相容性及溶质清除能力的临床研究[D].首都医科大学,2011.
[31]Nakata H, Sugitani S, Yamaji S, et al. Pancreatitis with pancreatic tail swelling associated with incretin-based therapies detected radiologically in two cases of diabetic patients with end-stage renal disease. Intern Med. 2012;51(21):3045-3049..
[32]赵天然.不同透析膜对血液透析患者IL-18表达水平的影响[D].河北医科大学,2006.
[33]Abramova N. Application of an ion-selective field effect transistor with a photocured polymer membrane in nephrology for determination of potassium ions in dialysis solutions and in blood plasma. Talanta.2000; 52(3): 533-538.
[34]Gika HG, Michopoulos F, Divanis D, et al. Daptomycin determination by liquid chromatography-mass spectrometry in peritoneal fluid, blood plasma, and urine of clinical patients receiving peritoneal dialysis treatment. Anal Bioanal Chem. 2010;397(6):2191-2197.
[35]Borazan A, Ustun H, Yilmaz A. The effects of hemodialysis andperitoneal dialysis on serum lipoprotein and C-reactive protein levels. J Int Med Res. 2003;31(5):378-383.
[36]Schindler R, Boenisch O, Fischer C, et al. Effect of the hemodialysis membrane on the inflammatory reaction in vivo. Clin Nephrol.2000;53(6):452-459.
[37]冯德辉.血液透析膜材料在重症胰腺炎领域的应用[J].中国组织工程研究与临床康复,2011,15(29):5417-5420.
[38]Pertosa G, Grandaliano G, Gesualdo L, et al. Clinical relevance of cytokine production inhemodialysis. Kidney Int. 2000;58(76):s104-s111.
[39]Chatenoud L, herbelin A, Beaurain G, et al. Immune deficiency of the uremic patients. Adv Nephrol. 1990; 19:259-274.
[40]田津生,XU Jin-sheng,张怡静,等.不同透析膜对血透患者血清C-反应蛋白及白细胞介素-6水平的影响[J].实用医学杂志,2008,24(15):2593-2595.