Effects of oscillating electric field on Wnt-3a expression and motor function in the injured rat spinal cord

doi:10.3969/j.issn.2095-4344.2016.18.010

Abstract

Abstract:

BACKGROUND: Wnt signaling pathways can stimulate the proliferation and differentiation of neural stem cells, and promote the repair of spinal cord injury. The electrical field stimulation can change the protein expression of Wnt signaling pathways.

QBJECTIVE: To explore the influence of oscillating electric field on motor function recovery and the expression of Wnt-3a protein in rats with spinal cord injury.

METHODS: A total of 36 Sprague-Dawley rats models with spinal cord injury were induced by the Allen’s method. All rats were randomly divided into oscillating electric field stimulation group and spinal cord injury group. The stimulating electrodes were added in both groups. The oscillating electric field stimulation group received oscillating electric field intervention.

RESULTS AND CONCLUSION: At 3 days after model establishment, Basso, Beattie, and Bresnahan (BBB) locomotor rating scale scores and Wnt-3a expression were similar between the oscillating electric field stimulation group and spinal cord injury group. At 7 and 14 days, significant differences in BBB scores and Wnt-3a expression were detected. These results indicate that oscillating electric field stimulation can activate Wnt signaling protein in the early stage of spinal cord injury, which may be associated with the promoting effect of oscillating electric field stimulation on spinal cord injury.
中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

Key words: Spinal Cord Injuries, Electrodes, Wnt Proteins, Tissue Engineering

Huang Xian-jia, Qian Jun, Zhang Kun-kun, Pan Wei-dong, Jing Jue-hua. Effects of oscillating electric field on Wnt-3a expression and motor function in the injured rat spinal cord[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(18): 2648-2654.

Figures/Tables 4

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