Autologous peripheral blood stem cell transplantation combined with percutaneous transluminal angioplasty for diabetic lower extremity vascular disease

doi:10.3969/j.issn.2095-4344.2016.14.016

Abstract

Abstract:

BACKGROUND: Studies have found that peripheral blood stem cells can highly differentiate into vascular endothelial cells to promote blood vessel regeneration, and improve collateral circulation, thereby achieving satisfactory outcomes in the treatment of limb ischemia.

OBJECTIVE: To observe the clinical effect in diabetic lower extremity vascular disease patients undergoing percutaneous transluminal angioplasty combined with autologous peripheral blood stem cell transplantation.

METHODS: Fifty patients hospitalized for diabetic lower extremity vascular disease from March in 2011 to December in 2014 were collected: 25 cases underwent percutaneous transluminal angioplasty as control group; another 25 underwent percutaneous transluminal angioplasty combined with autologous peripheral blood stem cell transplantation as combination group. At 1, 6, 12 months after surgery, subjective scores of affected limb pain and cold sensation were recorded, additionally, objective indicators, including ankle-brachial index, transcutaneous oxygen partial pressure, and claudication distance were detected.

RESULTS AND CONCLUSION: Ankle-brachial index scores of the two groups were significantly increased, especially at 1 month after surgery, but decreased at 6, 12 months, and there was a significant difference compared with that before treatment (P < 0.05); at 1, 6, and 12 months, there was no significant difference between the two groups (P > 0.05). At 1, 6, and 12 months after surgery, both of transcutaneous oxygen partial pressure and claudication distance in the two groups were significantly increased compared with those before treatment (P < 0.05). Furthermore, compared with the control group, these two indicators in the combination group were significantly increased (P < 0.05). Within 12-month follow-up, affected limb pain and cold sensation were improved in the two groups, especially in the combination group. Inevitably, three cases had hypocalcemia during the collection of peripheral blood stem cells, and two cases developed fever and 3 cases appeared to have local exudation after surgery. All these symptoms were released by symptomatic treatments, respectively. In conclusion, percutaneous transluminal angioplasty combined with autologous peripheral blood stem cell transplantation for diabetic lower extremity vascular lesions can promote the establishment of affected limb collateral circulation, to decrease the risk of limb ischemia, which achieves significant outcomes than percutaneous transluminal angioplasty used alone.
中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Peripheral Blood Stem Cell Transplantation, Angioplasty, Diabetic Angiopathies, Tissue Engineering

Gu Lu, Zhang Shu-mei, Yu Xiang, Yang Yi. Autologous peripheral blood stem cell transplantation combined with percutaneous transluminal angioplasty for diabetic lower extremity vascular disease[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(14): 2086-2091.

Figures/Tables 4

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