Bone marrow mesenchymal stem cells transplanted into a rat model of Alzheimer’s disease: improvement in the learning and memory ability

doi:10.3969/j.issn.2095-4344.2016.14.012

Abstract

Abstract:

BACKGROUND: Drug therapy can partly reduce and delay the progress of Alzheimer’s disease, but only 30% with the single drug treatment obtain clinical cure.
OBJECTIVE: To study the therapeutic effect of bone marrow mesenchymal stem cells transplantation for rats with Alzheimer’s disease.
METHODS: Amyloid β-protein was injected into the hippocampus of Sprague-Dawley rats to construct the model of Alzheimer’s disease. And bone marrow stromal stem cells were transplanted into the hippocampus of the rat models.
RESULTS AND CONCLUSION: At 2 weeks after modeling, compared with the control group, the escape latency in the model and experimental groups was significantly longer (P < 0.05), which indicating that Alzheimer’s disease models were successfully established. At 4 weeks after cell transplantation, compared with the model group, the average escape latency in the experimental group was significantly decreased, but retention time on the platform quadrant was significantly prolonged (P < 0.05). Besides, at 4 weeks after cell transplantation, expression of choline acetyltransferase in the experimental group was significantly higher than that in the model group (P < 0.05). In conclusion, bone marrow mesenchymal stem cells cannot only differentiate and survive in the hippocampus of rats with Alzheimer’s disease, but also improve the learning and memory ability.
中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Stem Cells, Tissue Engineering, Alzheimer Disease

Gao Ming-long, Zhang Ying-dong, Li Na, Qiao Jun, Yu Ming. Bone marrow mesenchymal stem cells transplanted into a rat model of Alzheimer’s disease: improvement in the learning and memory ability[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(14): 2059-2065.

Figures/Tables 4

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