Biocompatibility of Fe-Cr-Mo soft magnetic alloy with chromium plating

doi:10.3969/j.issn.2095-4344.2015.47.021

Abstract

Abstract:

BACKGROUND: Studies have demonstrated that Fe-Cr-Mo soft magnetic alloy has desired magnetic properties and machining properties. Surface Cr⁶⁺ plating treatment can significantly enhance the corrosion resistance in oral environment, but its biosecurity needs further testing.

OBJECTIVE: To evaluate the biocompatibility of Fe-Cr-Mo soft magnetic alloy with chromium plating.

METHODS: Logarithmic growth phase L929 cell suspension was obtained and seeded in 96-well plates at a cell concentration of 6×10⁷/L. Pure titanium extract, Fe-Cr-Mo soft magnetic alloy original extract, Cr⁶⁺-plated Fe-Cr-Mo soft magnetic alloy and PVC extract were added respectively. After 5 days of culture, cell morphology and adherent circumstances were observed. The absorbance value was detected using cell counting kit-8 assay. The relative growth rate of cells in each group was calculated. The cytotoxicity grades of materials were evaluated.

RESULTS AND CONCLUSION: In the pure titanium extracts group, the cells with normal morphology showed good adherent growth and no cytotoxicity. In the Fe-Cr-Mo soft magnetic alloy original extract group, the cell morphology and growth status were both good, with occasionally individual cell lysis. Scattered reddish brown particles were visible in the culture solution, showing no or very mild cytotoxicity. In Cr⁶⁺-plated Fe-Cr-Mo soft magnetic alloy extract group, the cells grew well and showed no or very mild cytotoxicity. In PVC extract group, more than 70% of cells were vacuole-shaped and presented with pyknosis or dissolution, there was a large number of cell debris, and cell growth was inhibited in over 50% cells, showing moderate cytotoxicity or above. The cytotoxicity of Cr⁶⁺-plated Fe-Cr-Mo soft magnetic alloy extract was grade 0-1. These results demonstrate that Fe-Cr-Mo soft magnetic alloy with chromium plating has good biocompatibility.
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Vitallium, Biocompatible Materials, Chromium, Tissue Engineering

Xia Yin-hua, Nie Er-min, Jiang Rui, Zhang Chun-yuan, Zeng Jin-di, Tan Ji-zhou. Biocompatibility of Fe-Cr-Mo soft magnetic alloy with chromium plating[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(47): 7660-7664.

Figures/Tables 5

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