Effect of percutaneous kyphoplasty bone cement injection on biomechanics of adjacent lumbar spine in animal models with osteoporosis

doi:10.3969/j.issn.2095-4344.2015.44.023

Abstract

Abstract:

BACKGROUND: Adjacent vertebral secondary fracture after operation is the most common complication of percutaneous kyphoplasty bone cement injection. Studying the effects of percutaneous kyphoplasty bone cement injection on biomechanical function of adjacent lumbar spine in animal model with osteoporosis will have some guiding significance for clinical practice.
OBJECTIVE: To investigate the effects of percutaneous kyphoplasty bone cement injection on biomechanical function of adjacent lumbar spine in rabbit models with osteoporosis.
METHODS: Thirty-six New Zealand female white rabbits were ovariectomized to establish L3 vertebral osteoporotic fracture model, and then randomly and evenly divided into control group (treated with open reduction and internal fixation operation) and experimental group (treated with percutaneous kyphoplasty bone cement
injection). At the 5th, 10th and 15th months after operation, L2, L4 bone mineral density, L2, L4 maximum bending and compressive load, the ratio of anterior and posterior heights of L3 vertebrae to average height of L2 and L4 vertebrae, and the sagittal Cobb angle of L2 and L4 vertebrae were detected.
RESULTS AND CONCLUSION: The bone mineral density, maximum bending and compressive load, vertebral height ratio at different time points after operation in experimental group were higher compared with the preoperative level (P < 0.05). The sagittal Cobb angle in experimental group was smaller compared with the preoperative level (P < 0.05). In the control group, the bone mineral density, maximum bending and compressive load at different time points after operation were all higher compared with preoperative level (P < 0.05). There were no significant difference of the vertebral height ratio and sagittal Cobb angle compared with the preoperative level. The bone mineral density, maximum bending and compressive load, vertebral height ratio at different time points after operation in experimental group were higher compared with the control group (P < 0.05). The sagittal Cobb angle was smaller compared with the control group (P < 0.05). These results demonstrate that percutaneous kyphoplasty bone cement injection can better improve the bone density, carrying capacity and kyphosis of osteoporosis fractures adjacent vertebrae.
中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Osteoporotic Fractures, Vertebroplasty, Biomechanics, Tissue Engineering

Aimaijiang Kuerban, Fan Shun-wu, Liu Chao, Wang Yin-kui, Shen Hong-da. Effect of percutaneous kyphoplasty bone cement injection on biomechanics of adjacent lumbar spine in animal models with osteoporosis[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(44): 7177-7181.

Figures/Tables 3

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