Biocompatibility of Ti35Nb3Zr2Ta, a new beta-titanium alloy, as joint prosthesis material

doi:10.3969/j.issn.2095-4344.2015.34.024

Abstract

Abstract:

BACKGROUND: Ti6Al4V is a titanium alloy that is widely used in human joint replacement, but its modulus of elasticity is greater than human bone, resulting in the bad stability of the prosthesis. Ti35Nb3Zr2Ta, a new β titanium alloy, has a lower modulus of elasticity, and maybe becomes a new-generation human joint prosthesis material that has a better biocompatibility.

OBJECTIVE: To study the biocompatibility of Ti35Nb3Zr2Ta in prosthesis.

METHODS: Wanfang, CNKI and PubMed databases were retrieved using a computer with “new β titanium; prosthesis; biocompatible” as keywords, and the retrieval time ranged from 2010 to 2015. Articles focusing on current application status for medical prosthesis materials and the biocompatibility of Ti35Nb3Zr2Ta in prosthesis were selected.

RESULTS AND CONCLUSION: Compared with Ti6Al4V, Ti35Nb3Zr2Ta has higher surface roughness and smaller surface contact angle; the alkaline phosphatase activity and amount of calcium deposits in osteoblasts cultured at Ti35Nb3Zr2Ta is significantly higher than that at Ti6Al4V. Ti35Nb3Zr2Ta has good biocompatibility, and can be considered to be widely used as joint prosthesis material further.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Titanium, Joint Prosthesis, Biocompatible Materials, Bioprosthesis

CLC Number:

R318

Duan Yong-gang, Ding Ying-qi, Zhang Long, Liu Yu-zhang, Tang Xiao-long. Biocompatibility of Ti35Nb3Zr2Ta, a new beta-titanium alloy, as joint prosthesis material[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(34): 5536-5540.

Figures/Tables 2

References

[1] 张君,林捷,郑志强,等.自粘接树脂水门汀对口腔修复用金属材料剪切粘接强度的影响[J].实用口腔医学杂志,2014,30(3): 336-339.
[2] 刘月,王晓萍,吴斌,等.不同牙科金属材料致敏性的比较[J].上海口腔医学,2014,23(2):143-148.
[3] 孟贺,丁洁,李任,等.4种牙科金属材料对成纤维细胞L929凋亡相关基因及蛋白表达的影响[J].华西口腔医学杂志,2013,31(3): 242-246.
[4] Chen J, Chen C, Chen Z, et al. Collagen/heparin coating on titanium surface improves the biocompatibility of titanium applied as a blood-contacting biomaterial. J Biomed Mater Res A. 2010;95(2):341-349.
[5] Ge S, Wang Y, Tian J, et al. An in vitro study on the biocompatibility of WE magnesium alloys. J Biomed Mater Res B Appl Biomater. 2015. in press.
[6] 王文革,邹兴政,王宏,等.一种新型医用高氮无镍不锈钢的生物相容性研究[J].功能材料,2013,44(16):2362-2366.
[7] 王宏刚,葛淑萍,邹兴政.医用高氮无镍奥氏体不锈钢的制备与生物相容性研究[J].功能材料,2012,43(18):2483-2487.
[8] 曹秀中,韩秀全,盖鹏涛.表面完整性对Ti6Al4V钛合金疲劳性能的影响[J].航空制造技术,2014(14):95-97,100.
[9] 付鹏飞,毛智勇,唐振云,等.薄板Ti6Al4V钛合金电子束焊接组织性能分析[J].焊接,2013(2):50-52,71-72.
[10] 赵光菊,郭献忠,毛宗良.Ti6Al4V高锁螺栓疲劳断口形貌及断口分析[J].贵州大学学报(自然科学版),2012,29(3):44-46.
[11] 余森,于振涛,韩建业,等.医用钛合金Ti-3Zr-2Sn-3Mo-25Nb表面自组装抗凝血复合涂层的构建及其血液相容性[J].中国有色金属学报(英文版),2012,22(12):3046-3052.
[12] 王凤彪,狄士春.多孔ZrO2/HA医用钛合金微弧氧化复合陶瓷膜层生物力学性能研究[J].稀有金属材料与工程,2012,41(2): 298-303.
[13] 王盼,郑长黎,文继舫,等.新型医用钛合金Ti-25Nb-10Ta-1Zr-0.2 Fe的细胞毒性研究[J].中南大学学报(医学版),2012,37(12):79.
[14] 王盼.新型医用钛合金Ti-25Nb-10Ta-1Zr-0.2Fe(TNTZ)的生物相容性研究[D].长沙:中南大学,2012.
[15] Niinomi M. Metallic biomaterials. J Artif Organs. 2008;11(3): 105-110.
[16] Li Z, Kawashita M. Current progress in inorganic artificial biomaterials. J Artif Organs. 2011;14(3):163-170.
[17] Niinomi M, Nakai M, Hieda J. Development of new metallic alloys for biomedical applications. Acta Biomater. 2012;8(11): 3888-3903.
[18] Zhao X, Niinomi M, Nakai M, et al. Optimization of Cr content of metastable β-type Ti-Cr alloys with changeable Young's modulus for spinal fixation applications. Acta Biomater. 2012; 8(6):2392-2400.
[19] Gao S, Zhai Y, Hu J. Study of blood compatibility on TiO2 coated biomedical Ni-Ti shape memory alloy. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2011;28(5):968-971, 1000.
[20] Kesteven J, Kannan MB, Walter R, et al. Low elastic modulus Ti-Ta alloys for load-bearing permanent implants: enhancing the biodegradation resistance by electrochemical surface engineering. Mater Sci Eng C Mater Biol Appl. 2015;46: 226-231.
[21] Laheurte P, Prima F, Eberhardt A, et al. Mechanical properties of low modulus beta titanium alloys designed from the electronic approach. J Mech Behav Biomed Mater. 2010; 3(8):565-573.
[22] Li Q, Niinomi M, Hieda J, et al. Deformation-induced ω phase in modified Ti-29Nb-13Ta-4.6Zr alloy by Cr addition. Acta Biomater. 2013;9(8):8027-8035.
[23] Zhao X, Niinomi M, Nakai M, et al. Microstructures and mechanical properties of metastable Ti-30Zr-(Cr, Mo) alloys with changeable Young's modulus for spinal fixation applications. Acta Biomater. 2011;7(8):3230-3236.
[24] 李利利,潘路军,李大卫,等.不锈钢基板上合成碳纳米线圈及其场发射特性[J].新型炭材料,2014(1):34-40.
[25] 陈文怡,周建,胡明.超细晶不锈钢/TiC复合材料的电化学腐蚀行为[J].稀有金属材料与工程,2013,42(10):2068-2072.
[26] 袁军平,李卫.含银和铌抗菌316L不锈钢的研究[J].稀有金属材料与工程,2013,42(10): 2004-2008.
[27] 朱康平,祝建雯,曲恒磊.国外生物医用钛合金的发展现状[J].稀有金属材料与工程,2012,41(11):2058-2063.
[28] 崔文芳,金磊,马艳,等.冷轧医用β钛合金显微组织和力学性能演变规律研究[J].稀有金属材料与工程,2013,42(10): 2034-2038.
[29] 王松,廖振华,刘伟强.医用钛合金热氧化处理工艺及其耐磨损、耐腐蚀性能和生物活性的研究进展[J].中国有色金属学报, 2014, (6):1466-1473.
[30] 程萌旗,郭永园,陈德胜,等.新型人工关节假体材料β钛合金Ti35Nb3Zr2Ta的生物相容性研究[J].中国矫形外科杂志,2013, 21(10):1017-1024.
[31] 李轩,石春来,王雪艳,等.心血管支架材料生物相容性:国际发展态势的文献计量学分析[J].中国组织工程研究,2015,19(8): 1267-1271.
[32] 金芮竹,赵驰.镍铬合金材料与口腔软组织的生物相容性[J].中国组织工程研究,2012,16(21):3949-3958.
[33] 刘冠花,王金清,刘晓辉,等.钛合金表面纳米氧化锌薄膜制备及抗菌性研究[J].中国现代医学杂志,2014,24(32):1-4.
[34] 张文毓.生物医用钛合金的研究进展[J].化学与粘合,2014,36(5): 369-373.
[35] 谭兆军,郭亚峰.口腔修复用钛及钛合金的理化特性及其生物相容性[J].中国组织工程研究与临床康复,2008,12(19): 3721- 3724.
[36] Olivares-Navarrete R, Hyzy SL, Hutton DL, et al. Role of non-canonical Wnt signaling in osteoblast maturation on microstructured titanium surfaces. Acta Biomater. 2011;7(6): 2740-2750.
[37] Vlacic-Zischke J, Hamlet SM, Friis T, et al. The influence of surface microroughness and hydrophilicity of titanium on the up-regulation of TGFβ/BMP signalling in osteoblasts. Biomaterials. 2011;32(3):665-671.
[38] Gu YX, Du J, Si MS, et al. The roles of PI3K/Akt signaling pathway in regulating MC3T3-E1 preosteoblast proliferation and differentiation on SLA and SLActive titanium surfaces. J Biomed Mater Res A. 2013;101(3):748-754.
[39] Chakravorty N, Ivanovski S, Prasadam I, et al. The microRNA expression signature on modified titanium implant surfaces influences genetic mechanisms leading to osteogenic differentiation. Acta Biomater. 2012;8(9):3516-3523.
[40] Ziebart T, Schnell A, Walter C, et al. Interactions between endothelial progenitor cells (EPC) and titanium implant surfaces. Clin Oral Investig. 2013;17(1):301-309.
[41] Miron RJ, Oates CJ, Molenberg A, et al. The effect of enamel matrix proteins on the spreading, proliferation and differentiation of osteoblasts cultured on titanium surfaces. Biomaterials. 2010;31(3):449-460.
[42] Klein MO, Bijelic A, Toyoshima T, et al. Long-term response of osteogenic cells on micron and submicron-scale-structured hydrophilic titanium surfaces: sequence of cell proliferation and cell differentiation. Clin Oral Implants Res. 2010;21(6): 642-649.
[43] Galli C, Piemontese M, Lumetti S, et al. GSK3b-inhibitor lithium chloride enhances activation of Wnt canonical signaling and osteoblast differentiation on hydrophilic titanium surfaces. Clin Oral Implants Res. 2013;24(8):921-927.
[44] An N, Rausch-fan X, Wieland M, et al. Initial attachment, subsequent cell proliferation/viability and gene expression of epithelial cells related to attachment and wound healing in response to different titanium surfaces. Dent Mater. 2012; 28(12):1207-1214.
[45] Hamlet S, Alfarsi M, George R, et al. The effect of hydrophilic titanium surface modification on macrophage inflammatory cytokine gene expression. Clin Oral Implants Res. 2012;23(5): 584-590.
[46] Chakravorty N, Hamlet S, Jaiprakash A, et al. Pro-osteogenic topographical cues promote early activation of osteoprogenitor differentiation via enhanced TGFβ, Wnt, and Notch signaling. Clin Oral Implants Res. 2014;25(4):475-486.
[47] Hyzy SL, Olivares-Navarrete R, Hutton DL, et al. Microstructured titanium regulates interleukin production by osteoblasts, an effect modulated by exogenous BMP-2. Acta Biomater. 2013;9(3):5821-5829.
[48] Olivares-Navarrete R, Hyzy S, Wieland M, et al. The roles of Wnt signaling modulators Dickkopf-1 (Dkk1) and Dickkopf-2 (Dkk2) and cell maturation state in osteogenesis on microstructured titanium surfaces. Biomaterials. 2010;31(8): 2015-2024.
[49] Klein MO, Bijelic A, Ziebart T, et al. Submicron scale-structured hydrophilic titanium surfaces promote early osteogenic gene response for cell adhesion and cell differentiation. Clin Implant Dent Relat Res. 2013;15(2): 166-175.
[50] Wu Y, Zitelli JP, TenHuisen KS, et al. Differential response of Staphylococci and osteoblasts to varying titanium surface roughness. Biomaterials. 2011;32(4):951-960.
[51] Park JW, Kim YJ, Jang JH, et al. Positive modulation of osteogenesis- and osteoclastogenesis-related gene expression with strontium-containing microstructured Ti implants in rabbit cancellous bone. J Biomed Mater Res A. 2013;101(1):298-306.
[52] Alfarsi MA, Hamlet SM, Ivanovski S. The Effect of Platelet Proteins Released in Response to Titanium Implant Surfaces on Macrophage Pro-Inflammatory Cytokine Gene Expression. Clin Implant Dent Relat Res. 2014. in press.
[53] Lai HC, Zhuang LF, Liu X, et al. The influence of surface energy on early adherent events of osteoblast on titanium substrates. J Biomed Mater Res A. 2010;93(1):289-296.
[54] Olivares-Navarrete R, Hyzy SL, Hutton DL, et al. Role of non-canonical Wnt signaling in osteoblast maturation on microstructured titanium surfaces. Acta Biomater. 2011; 7(6):2740-2750.
[55] Padial-Molina M, Galindo-Moreno P, Fernández-Barbero JE, et al. Role of wettability and nanoroughness on interactions between osteoblast and modified silicon surfaces. Acta Biomater. 2011;7(2):771-778.
[56] Sagomonyants KB, Hakim-Zargar M, Jhaveri A, et al. Porous tantalum stimulates the proliferation and osteogenesis of osteoblasts from elderly female patients. J Orthop Res. 2011; 29(4):609-616.
[57] 何蕾.植入物用Ti-13Nb-13Zr合金电化学性能的研究[J].钛工业进展,2014(3):43-44.