Role of stromal cell-derived factor 1/CXC chemokine receptor axis in rat tooth movement

doi:10.3969/j.issn.2095-4344.2017.36.004

Abstract

Abstract:

BACKGROUND: Orthodontic treatment has a long course and referral interval, which is an important difficulty. How to accelerate orthodontic tooth movement is an issue of concern.
OBJECTIVE: To testify whether the local injection of AMD3100 (CXCR4 antagonist) can accelerate the tooth movement or not, and to explore the role of stromal cell-derived factor 1/CXC chemokine receptor axis in tooth movement.
METHODS: Ninety Sprague-Dawley rats aged 8-10 weeks old were selected and the models of orthodontic tooth movement were established. The model rats were randomized into three groups, and then given the injection of stromal cell-derived factor 1, AMD3100 or PBS. The rats were killed at 1, 3, 5, 7, 10 and 14 days to measure the tooth movement distance.
RESULTS AND CONCLUSION: The tooth movement distance showed difference among three groups; AMD3100 could facilitate the tooth movement, while stromal cell-derived factor 1 exerted inhibitory effect on the tooth movement. To conclude, stromal cell-derived factor 1/CXC chemokine receptor axis plays an important role in tooth movement.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Receptors, CXCR4, Tooth Movement, Tissue Engineering

CLC Number:

R318

Cheng Qian1, Lin Fu-wei1, Xie Yi-jia1, Huang Yue1, Wang Jun2. Role of stromal cell-derived factor 1/CXC chemokine receptor axis in rat tooth movement[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(36): 5757-5762.

Figures/Tables 1

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