Performance characterization of bacterial cellulose reinforced polyvinyl alcohol/ polyacrylamide composite hydrogels

doi:10.3969/j.issn.2095-4344.2017.30.019

Abstract

Abstract:

BACKGROUND: With the extension of the application of polymer hydrogel materials, to develop polymer hydrogel materials with better performance has become a hotspot.

OBJECTIVE: To compare the mechanical properties of polyvinyl alcohol/polyacrylamide (PVA/PAM) composite hydrogel before and after modification by bacterial cellulose (BC), thereby providing a theoretic basis for its application in wound dressing.

METHODS: BC-reinforced PVA/PAM hydrogels with different PVA/PAM contents were prepared using repeated freezing-thaw method. The BC/PVA/PAM hydrogels were characterized by infrared spectrum (IR) analysis, mechanical property test and scanning electron microscopy (SEM) observation, and thermogravimetric analysis.

RESULTS AND CONCLUSION: SEM and IR results showed the PVA and PAM were combined and attached onto the surface of BC, indicating a success in the preparation of BC/PVA/PAM hydrogels. Results from the thermogravimetric analysis showed that the thermal-stability of the BC/PVA/PAM hydrogels improved significantly. The mechanical test results demonstrated that the tensile strength of the PVA/PAM hydrogels was strongly enhanced, and the elongation at break was significantly lowered after being reinforced with BC. Furthermore, the content of PVA and PAM had an obvious effect on the mechanical properties of the composites. When the PAM content was 1.0%, the tensile strength and elongation at break of BC/PVA/PAM composites were at the highest level, which were 331.79 kPa and 105.33%, respectively; when the PVA content was 3.5%, the elongation at break of the BC/PVA/PAM composites was increased to the maximum (46.25%). Moreover, the results of this work reveal that the BC/PVA/PAM hydrogels exhibit some promising characteristics as artificial biomaterials. In general, the introduction of bacterial cellulose significantly improves the mechanical properties of the PVA/PAM hydrogels, and enhances the stability of the BC/PVA/PAM.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Cellulose, Hydrogel, Acrylamides, Tissue Engineering

CLC Number:

R318

Ma Biao, Dong Yan-yan, Chen Shi-wen.

Performance characterization of bacterial cellulose reinforced polyvinyl alcohol/ polyacrylamide composite hydrogels

[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(30): 4867-4872.

Figures/Tables 4

.4 力学性能分析结果图4A和4B给出了聚乙烯醇含量对细菌纤维素増强前和细菌纤维素增强后的纯聚合物凝胶和细菌纤维素增强复合凝胶力学性能的影响。结果表明随着聚乙烯醇含量的增加，PVA/PAM和BC/PVA/PAM复合凝胶的拉伸强度呈增加趋势，这是由于聚乙烯醇的机械强度好及细菌纤维素本身的机械强度高，因此PVA/PAM复合膜体系引入细菌纤维素后的拉伸强度更高，而对于断裂伸长率而言，细菌纤维素增强复合凝胶断裂伸长率比纯聚合物凝胶明显降低，当聚乙烯醇含量为3.5%时，纯凝胶和增强后水凝胶的断裂伸长率均达到最大分别为136.09%，46.25%，而林建明等[41]采用水溶液聚合法得到的PVA/ PAM互穿网络水凝胶的最大断裂伸长率可达3 000%，本实验相比该数值较小，是因为两者的制备方法不同，主要是由于前者采用的是两步水溶液聚合法制备的，而本实验是用冷冻-解冻法制备的。对比引入细菌纤维素前后的复合凝胶可知，细菌纤维素的引入对PVA/PAM水凝胶起到明显的増强作用，说明BC/PVA/PAM复合水凝胶具有足够的韧性，可应用于伤口敷料方面。图4C和4D是聚丙烯酰胺含量对细菌纤维素增强前和细菌纤维素增强后的纯聚合物凝胶和细菌纤维素增强复合凝胶力学性能的影响。结果显示加入少量聚丙烯酰胺 (< 1.0%)后，纯聚合物凝胶和细菌纤维素增强复合凝胶的拉伸强度随聚丙烯酰胺增加而增加，这是因为聚丙烯酰胺的力学性能差，而拉伸强度增加的主要原因是聚丙烯酰胺浓度提高，与聚乙烯醇形成的氨键数增多，当聚丙烯酰胺浓度为1.0%时细菌纤维素增强复合凝胶的拉伸强度达到最大为331.79 kPa，断裂伸长率为105.33%，但继续加入聚丙烯酰胺后，力学性能会趋于稳定或下降，这主要是由于少量聚丙烯酰胺对聚乙烯醇的结晶有促进作用，随着聚丙烯酰胺含量的增加，由聚丙烯酰胺形成的连续相区扩大，此时聚丙烯酰胺不仅难以起到增强作用，反而由于本身韧性较差，成为新的缺陷源[42-43]。断裂伸长率比増强前下降是由于细菌纤维素的引入限制了PVA/PVM网络的运动。"

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