Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (29): 4368-4375.doi: 10.3969/j.issn.2095-4344.2016.29.016

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Construction strategies for tissue-engineered ligaments

Di Ya-long1, Han Chang-xu2, Zhao Liang1, Ren Yi-zhong2   

  1. 1Graduate School, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China; 2the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China
  • Received:2016-04-16 Online:2016-07-08 Published:2016-07-08
  • Contact: Ren Yi-zhong, Master, Chief physician, the Second Affiliated Hospital of Inner Mongolia Medical University Hohhot 010030, Inner Mongolia Autonomous Region, China
  • About author:Di Ya-long, Studying for master’s degree, Physician, Graduate School, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China

Abstract:

BACKGROUND: Until now, musculoskeletal bioengineering used in the orthopedic surgery and regenerative medicine are developing.
OBJECTIVE: To summarize the construction strategies for tissue-engineered knee ligaments.
METHODS: A computer-based online search was conducted in PubMed to screen the relevant literatures using the terms “knee ligament” AND “tissue engineering” OR “regenerative medicine”. The literature retrieval, data assessment and extraction were performed by both authors independently. The relevant literatures were included through reviewing preclinical and clinical studies to display the preclinical and clinical medicine progresses in the construction strategies for tissue-engineered ligaments.
RESULTS AND CONCLUSION: Included 224 literatures focus on the construction strategies for tissue-engineered ligaments, including stem cell therapy, growth factors, biomaterials and scaffolds, and mechanical stimulation pattern. Construction techniques for tissue-engineered ligaments have some potential advantages, such as rapid function recovery, good tenacity, and reduced relapse. However, rigorous and high-level randomized controlled clinical trials are needed for the translation of preclinical results into successful clinical trials.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Ligaments, Regenerative Medicine, Tissue Engineering

CLC Number: