Continuous monitoring of peripheral blood retinol blinding protein-4 in the early stage after renal transplantation

doi:10.3969/j.issn.2095-4344.2015.46.018

Abstract

Abstract:

BACKGROUND: Retinol binding protein-4 is a most sensitive biomarker for loss of function of the human proximal renal tubule, which is applied in the early detection of acute kidney injury. It is speculated that retinol binding protein-4 may be associated with acute rejection and delayed graft function after renal transplantation.

OBJECTIVE: To investigate the correlation of peripheral blood retinol binding protein-4 and renal allograft function in the early stage after renal transplantation.

METHODS: The venous blood samples of renal transplantation recipients were continuously collected for detection. As a retrospective nested case-control study, 20 cases of clinical diagnosed acute rejection were selected as acute rejection group. Another 20 cases of delayed graft function and 20 cases with normal graft function were randomly selected according to the ratio of 1:1:1 and taken as delayed graft function group and control group, respectively. Retinol binding protein-4 level was detected by the immune turbidimetric method, and meanwhile, the serum creatinine and blood urea nitrogen levels were dynamically examined by the sarcosine oxidase method. Then, all the data were comparatively analyzed at vertical and horizontal levels.

RESULTS AND CONCLUSION: Compared with the control group, retinol binding protein-4 and serum creatinine levels in the acute rejection group and the delayed graft function group were significantly higher (P < 0.05). Retinol binding protein-4 and serum creatinine levels in the acute rejection group were significantly different between the rejection and non-rejection periods (P < 0.01). Similarly, these two indicators in the delayed graft function group were significantly different between the normal and abnormal renal function periods (P < 0.05). Retinol binding protein-4 levels were positively correlated with serum creatinine and blood urea nitrogen levels. Both in the acute rejection group and delayed graft function group, retinol binding protein-4 levels changed earlier than the serum creatinine levels. Retinol binding protein-4, an independent biomarker indicator, is positively correlated with serum creatinine and blood urea nitrogen and has certain time advantage in predicting the change of renal function, which is very conducive to the clinical diagnosis and monitoring of acute rejection and delayed graft function.
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Kidney Transplantation, Graft Rejection, Retinol-Binding Proteins, Delayed Graft Function

Zhou Yu, Zheng Xue-yang, Lu Han-lan, Chen Yu, Fu Shang-xi, Wang Li-ming. Continuous monitoring of peripheral blood retinol blinding protein-4 in the early stage after renal transplantation[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(46): 7472-7477.

Figures/Tables 8

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