Hemostasis effects of microporous polysaccharide hemostatic powder on soft tissue trauma

doi:10.3969/j.issn.2095-4344.2014.03.013

Abstract

Abstract:

BACKGROUND: A cross-emulsification patented product of microporous polysaccharide hemostatic powder was prepared using potatoes as raw material with independent intellectual property rights.
OBJECTIVE: To observe hemostasis effects of microporous polysaccharide hemostatic powder on soft tissue trauma.
METHODS: A wound, about 3 cm long and 0.5 cm deep, was made on the abdominal soft tissue of rabbits in the experimental group 1, and then microporous polysaccharide hemostatic powder, 1.0-2.0 g, was sprayed directly on the wound. In the experimental group 2, a wound, about 3.0 cm long and 1.0 cm deep, was made on the abdominal soft tissue of rabbits, and then microporous polysaccharide hemostatic powder, 1.0-2.0 g, was sprayed directly on the wound. Another rabbits with untreated wound served as controls.

RESULTS AND CONCLUSION: Microporous polysaccharide hemostatic powder formed a “pasty gel” covering the bleeding wound that achieved hemostatic effect. The bleeding time was (15.25±1.04) seconds in the experimental group 1 and (11.25±1.89) seconds in the experimental group 2. The marked effective and effective rates for hemostasis were 87.5% and 100%, respectively. In the control group, the bleeding time was more than 5 minutes. Hematoxylin-eosin staining showed mild muscle edema, vasodilatation of small blood vessels, and few scattered endoplasmic neutrophils infiltrated at 24 hours after treatment with microporous polysaccharide hemostatic powder; till the 7th day, inflammation subsided, mild fibrosis was visible on muscle tissue surface, the
hemostatic powder was completely absorbed, the wound tissue was close to the normal tissue, and there were no significant changes in muscle cells. These findings suggest that microporous polysaccharide hemostatic powder can be used for hemostasis of soft tissue trauma.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: biocompatible materials, hemostasis, soft tissue injuries, Solanum tuberosum

CLC Number:

R318

Shi Yue, Du Bao-tang, He Yuan-qing, Yin Wen-jing. Hemostasis effects of microporous polysaccharide hemostatic powder on soft tissue trauma[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(3): 406-411.

Figures/Tables 1

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