Performance testing of biodegradable mesh-like microporous balloon combined with calcium phosphate cement for vertebroplasty

doi:10.3969/j.issn.2095-4344.2014.12.003

Abstract

Abstract:

BACKGROUND: Vertebroplasty and kyphoplasty for osteoporotic vertebral compression fractures can result in many complications, such as bone cement leakage and adjacent-level fractures.
OBJECTIVE: To verify the possibility of biodegradable mesh-like microporous polymer balloon for the treatment of osteoporotic vertebral compression fractures.
METHODS: Biodegradable mesh-like microporous P(DLLA-CL) balloons were fabricated by electrospinning technique. Coated balloons with the same specification was fabricated by coating P(DLLA-CL) onto the same mould. Morphology of the balloons was observed by scanning electron microscopy. The balloon leakage was observed by eyes after the injection of water or cement. The initial strength and stiffness were measured by a universal testing machine. The proliferation of MC3T3-E1 cells on the balloons was determined by laser confocal microscope and cell counting kit-8 assays. The biodegradation of balloons in simulated body fluid, porcine pancreatic lipase, and fresh human serum was studied by residual weighing and scanning electron microscopy observation. Burst pressure of balloons was measured after the balloon was placed into a hole in the vertebral bone. For the in vitro calcium release tests, the balloons were filled with calcium cement, tied, placed into 6atm ultrapure water, and then the calcium concentration was regularly determined.
RESULTS AND CONCLUSION: Mesh-like microporous balloons presented with good fiber morphology, thickness distribution, and the presence of pores; on the coated balloon surface, there was absence of specific morphology and porosity. Compared with the coated balloon, the mesh-like microporous balloon showed better mechanical properties, liquid permeability and burst pressure, to prevent leakage of bone cement and promote osteoblast adhesion and proliferation. In addition, the degradation of the mesh-like microporous balloons was more uniform and stable than the coated balloons, which may increase the calcium concentration in the injured vertebrae and will be beneficial to the new bone growth and fracture healing.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: biocompatible materials, nanofibers, saccule and utricle, fractures

CLC Number:

R318

Liu Xun-wei, Zhong Jian, Peng Xiang-tao, Wei Dai-xu, Zhou Juan, Ye Yong, Sun Gang . Performance testing of biodegradable mesh-like microporous balloon combined with calcium phosphate cement for vertebroplasty[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(12): 1817-1823.

Figures/Tables 6

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