Chinese Journal of Tissue Engineering Research ›› 2020, Vol. 24 ›› Issue (29): 4717-4723.doi: 10.3969/j.issn.2095-4344.2711
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Chen Peishan, Zhang Haiyan
Department of Cell Biology, Basic Medical College, Capital Medical University, Beijing 100069, China
Received:
2019-11-16
Revised:
2019-11-20
Accepted:
2019-12-26
Online:
2020-10-18
Published:
2020-09-15
Contact:
Zhang Haiyan, Professor, Doctoral supervisor, Department of Cell Biology, Basic Medical College, Capital Medical University, Beijing 100069, China
About author:
Chen Peishan, Department of Cell Biology, Basic Medical College, Capital Medical University, Beijing 100069, China
Supported by:
the National Natural Science Foundation of China, No. 81770616
CLC Number:
Chen Peishan, Zhang Haiyan. Organs-on-a-chip and engineered human tissues in drug development[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(29): 4717-4723.
器官芯片的目的并不是建立一个完整的活体器官,而是建立一个用可控的方法来模拟某些人类生理条件下的最小功能单元。例如,将物理、化学或生物刺激施加于细胞上来模拟细胞在体内的信息传导,如电刺激下的心肌细胞;将细胞培养在特定的基膜上可以重新建立不同组织之间联系,如肺泡-毛细血管交换网和血脑屏障[1-2];以微流控芯片技术为研究平台,采用软光刻的方法制备了具有双层结构的微流控肿瘤细胞芯片[3]。对于大多数人体组织而言,器官芯片还需要考虑物理力学性能,如流体动力学、机械力学和电子学等特征。多种器官可以通过将单个的器官芯片以具有体积比和流量分布的微流体通道有机结合以实现生理功能的模拟,从而构建人体体外模型的子系统[4](见图1)。 "
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