Wnt/beta-catenin signaling pathway in the treatment of osteoarthritis: new advances and application prospects

doi:10.3969/j.issn.2095-4344.2714

Abstract

Abstract:

BACKGROUND: Wnt/β-catenin signaling pathway plays a vital role in the development of osteoarthritis. OBJECTIVE: To review the recent progress of treating osteoarthritis based on the Wnt/β-catenin signaling pathway.

METHODS: An electronical literature retrieval of PubMed, CNKI and WanFang databases was performed to search the literatures concerning the Wnt/β-catenin pathway in the treatment of osteoarthritis. The keywords

were “catenin; wnt; osteoarthritis;arthritis; degenerative; arthritides; deformans; pathway; wnt signaling; signaling pathway; wnt signaling pathways; wnt beta catenin signaling pathway; canonical wnt pathway; canonical wnt” in English and Chinese, respectively. Finally, 74 articles were included in result analysis.

RESULTS AND CONCLUSION: The potential treatments of osteoarthritis based on the Wnt/β-Catenin signal pathway include natural antagonists, small molecule inhibitors, agonists, traditional Chinese medicine and drug reposition. These drug pathways provide chondroprotective effect via activating or inhibiting the Wnt/β-catenin signaling pathway. The treatment of osteoarthritis based on the Wnt/β-catenin signaling pathway is currently in the laboratory stage, but it has a great application prospect. How to accurately regulate the pathway and better transfer the research results into the application will become a hotspot in the future.

Key words: osteoarthritis, Wnt/β-catenin, signaling pathway, cartilage

CLC Number:

Bei Tao, Liu Junting, Huang Qiulin, Su Wei, Zhao Jinmin. Wnt/beta-catenin signaling pathway in the treatment of osteoarthritis: new advances and application prospects[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(29): 4724-4730.

Figures/Tables 3

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