Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (1): 13-19.doi: 10.3969/j.issn.2095-4344.2157
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Received:
2020-02-10
Revised:
2020-02-18
Accepted:
2020-03-30
Online:
2021-01-08
Published:
2020-09-19
Contact:
Pan Xinghua, MD, Chief physician, Cell Biological Therapy Center of 920th Hospital of Joint Logistics Support Force of Chinese PLA, The Transfer Medicine Key Laboratory of Cell Therapy Technology of Yunan Province, The Integrated Engineering Laboratory of Cell Biological Medicine of State and Regions, Kunming 650032, Yunnan Province, China
About author:
Wang Yanying, Master candidate, Guizhou Medical University, Guiyang 550025, Guizhou Province, China; Cell Biological Therapy Center of 920th Hospital of Joint Logistics Support Force of Chinese PLA, The Transfer Medicine Key Laboratory of Cell Therapy Technology of Yunan Province, The Integrated Engineering Laboratory of Cell Biological Medicine of State and Regions, Kunming 650032, Yunnan Province, China
Supported by:
CLC Number:
Wang Yanying, Yang Yukun, Zhu Xiangqing, Li Ye, He Jie, Tian Chuan, He Zhixu, Pan Xinghua. Effects of bone marrow mesenchymal stem cell transplantation on thymus structure and function in the aging macaques[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(1): 13-19.
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2.2 实验动物数量分析 15只猕猴经过1周正常喂养后无异样变化,随机进行分组,即幼年组5只(n=5)、老年组4只(n=4)和老年治疗组6只(n=6),动物结果分析共计15只,中途15只猕猴无异样变化。 2.3 外周血T细胞和调节性T细胞输出水平变化 通过流式细胞术对老年治疗组猕猴外周血T细胞检测,CD3+T细胞在外周血中的百分比呈先升高后降低的趋势,治疗30 d和60 d 较治疗前显著增加(P < 0.05),治疗90 d较治疗前降低,但差异无显著性意义(P > 0.05);CD3+CD4+T细胞在外周血中的百分比呈缓慢增长趋势,治疗前与治疗30,60,90 d比较差异均无显著性意义(P > 0.05);CD3+CD8+T细胞在外周血中的百分比呈先升高后降低再升高的趋势,治疗前与治疗30,60,90 d比较差异均无显著性意义(P > 0.05)。 调节性T细胞在外周血中的百分比呈下降趋势,其中治疗30,60,90 d与治疗前比较差异均有显著性意义(P < 0.05),见图2和表1。 "
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