Chinese Journal of Tissue Engineering Research ›› 2017, Vol. 21 ›› Issue (36): 5830-5834.doi: 10.3969/j.issn.2095-4344.2017.36.016

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Ultrasound-induced transdermal drug delivery to the stellate ganglion as a countermeasure to sub-health state

Huang Shu-ting1, Zeng Qing2, Tang Xin-qun3, Huang Ying-yi4, Shao Xiao-hui4, Wang Ying-jie5, Huang Guo-zhi2   

  1. 1School of Rehabilitation Medicine, Southern Medical University, Guangzhou 510282, Guangdong Province, China; 2Department of Rehabilitation Medicine, 3Department of Pediatrics, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China; 4Department of Neurology, Guangzhou First People’s Hospital, Guangzhou 510515, Guangdong Province, China; 5the Second Clinical Medical School of Southern Medical University, Guangzhou 510282, Guangdong Province, China
  • Received:2017-07-25 Online:2017-12-28 Published:2018-01-04
  • Contact: Huang Guo-zhi, M.D., Chief physician, Professor, Doctoral supervisor, Department of Rehabilitation Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China
  • About author:Huang Shu-ting, School of Rehabilitation Medicine, Southern Medical University, Guangzhou 510282, Guangdong Province, China
  • Supported by:

    the Undergraduate Innovation Project of Guangdong Province, No. 1212110006; the Medical Science Research Foundation of Guangdong Province, No. 20161198360341

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Abstract:

BACKGROUND: Stellate ganglion block is feasible for the patients in sub-health status, but it is invasive and the patient compliance is poor.
OBJECTIVE: To investigate the clinical effectiveness of ultrasound-induced transdermal drug delivery for reducing the hyperactivity of the cervical sympathetic ganglia in the sub-health status.
METHODS: Sixty-nine participants in sub-health state from different age levels and professions were recruited and were randomly divided into treatment (n=31) and control (n=38) groups. The treatment group underwent ultrasound-induced transdermal drug delivery to the cervical sympathetic ganglia, while the control group received psychological counseling on sub-health education and behavior intervention. All patients were assessed with Sub-Health Measurement Scale Version1.0, and the Medical Outcomes Study 36-Item Short-Form Health Survey prior to and post treatment, along with clinical curative effect assessment.
RESULTS AND CONCLUSION: After treatment, 29 participants in the treatment group were improved or recovered from sub-health, with an effective rate of 93.5%. Compared with the control group, the scores were significantly improved in the treatment group. To conclude, ultrasound-induced transdermal drug delivery to the stellate ganglion has a significant effect on sub-health state.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Pulse Therapy, Drug, Stellate Ganglion, Health Status, Tissue Engineering

CLC Number: