Expression of Sox2 and Oct4 in relation to microvessel density in lung cancer tissues

doi:10.3969/j.issn.2095-4344.2017.13.024

Abstract

Abstract:

BACKGROUND: High expression of stem cell transcription factors, Sox2 and Oct4, has been confirmed to be closely related to the occurrence of lung cancer.
OBJECTIVE: To explore the expression of Sox2 and Oct4 in lung cancer tissues and its correlation with microvascular generation and clinical-pathologic features.
METHODS: The expression levels of Sox2 and Oct4 and microvessel density (MVD) in lung cancer tissues (60 cases) and normal tissues (60 cases) were examined by immunohislochemistry. Then, the correlation of the expression of Sox2 and Oct4 and MVD value with clinical-pathologic features in lung cancer was analyzed.
RESULTS AND CONCLUSION: The positive expression of Sox2 and Oct4 was 46.67% (28/60) and 71.67% (43/60) in lung cancer tissues, respectively, while Sox2 and Oct4 were negatively expressed in normal tissues, and there was a significant difference between lung cancer and normal tissues (P < 0.001). The MVD value was 16.22±2.18 in lung cancer tissues, which was significantly higher than that in normal tissues (4.36±2.07) (P < 0.001). Expression of Sox2, Oct4 and MVD value were correlated with TNM stage, differentiation degree, ymph node metastasis, vessel invasion, and liver metastasis (all P < 0.05), but not with the patient’s age and gender (both P > 0.05). The MVD value with Sox2 and Oct4 positive expression was significantly higher than that with Sox2 and Oct4 negative expression (P< 0.001). Spearmen analysis results showed that there was no correlation between Sox2 and Oct4 in lung cancer tissues (r=2.752,P > 0.05). To conclude, the high expression of Sox2 and Oct4 has a high correlation with the initiation and progression of lung cancer, and has positive correlation with the MVD, both of which are significantly concerned with the microvascular generation, invasion and hematogenous metastasis of lung cancer.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Lung Neoplasms, SOXB1 Transcription Factors, Octamer Transcription Factors, Microvessels, Tissue Engineering

CLC Number:

R394.2

Xiang Bao-li, Qian Hai-hong, Zhang Zhi-lin, Su Jing, Chen Li-ping, Zhang Zhi-hua. Expression of Sox2 and Oct4 in relation to microvessel density in lung cancer tissues[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(13): 2114-2119.

Figures/Tables 2

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