Preparation, transfer property and biocompatibility of the hollow fiber dialysis membrane

doi:10.3969/j.issn.2095-4344.2017.02.019

Abstract

Abstract:

BACKGROUND: Polysulfone membrane holds good anti-biodegradation ability, but how to use it to prepare hollow fiber dialysis membrane and its blood compatibility have not been fully understood.
OBJECTIVE: To study the preparation, transfer property and biocompatibility of hollow fiber dialysis membrane.
METHODS: With polysulfone as the film material, diethylene glycol as the porogen, polyvinyl pyrrolidone as the modifier, N, N-dimethylacetamide as the solvent, and the hollow fiber dialysis membrane was prepared using nonsolvent-induced phase separation. The performance was measured using scanning electron microscopy, ultra-depth three-dimensional microscope imaging and porosity test; the transfer parameters including reject rate and water flux were detected by ultrafiltration device; the blood compatibility was determined through hemolysis test, dynamic clotting time test and platelet adhesion test. Type II medical polyurethane material served as negative control.
RESULTS AND CONCLUSION: The section of hollow fiber dialysis membrane was asymmetric. 17% dialysis membrane showed a porous middle layer, while 19%, 21% and 23% membrane showed a sponge-like middle layer. Under the same membrane area, the density of fiber dialysis membrane was significantly lower than that of the negative control material, and the porosity of fiber dialysis membrane was significantly higher than that of the negative control material (P < 0.05). The water volume and water flux of the hollow fiber dialysis membrane were significantly higher than those of the negative control material (P < 0.05). Results from three hemolytic tests showed that the average absorbance values and hemolysis rate of the hollow fiber dialysis membrane were significantly higher than those of the negative control material (P < 0.05). The dynamic clotting time test and the platelet adhesion test revealed that the dynamic clotting time of hollow fiber dialysis membrane at 20, 40 and 70 minutes was significantly shorter than that of the negative control material (P < 0.05). These results suggest that polysiloxane can be used as the membrane material to prepare hollow fiber dialysis membrane using nonsolvent-induced phase separation, and holds a good biocompatibility, blood compatibility and transfer efficiency.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Tissue Engineering, Biocompatible Materials, Hemodialysis Solutions

CLC Number:

R318

Wang Shi-ying, Zhao Xin-xin, Shi Jun, Yang Su-xia, Sun Zhi-qiang .

Preparation, transfer property and biocompatibility of the hollow fiber dialysis membrane

[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(2): 268-272.

Figures/Tables 6

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