Synthesis of MnFe2O4 nanomicelles and its application in magnetic resonance molecular imaging

doi:10.3969/j.issn.2095-4344.2016.47.014

Abstract

Abstract:

BACKGROUND: Studies have shown that the saturation magnetization of nanoparticles can be increased by increasing of particle size of nanoparticles or cluster-like aggregation of multiple nanoparticles. But the increased particle size can reduce the cycle time of nanoparticles in the body.
OBJECTIVE: To synthesize MnFe₂O₄ nanomicelles and explore the feasibility of its application in magnetic resonance molecular imaging.
METHODS: MnFe₂O₄ nanoparticles were synthesized using thermal decomposition method and self-assembled with polyethylene glycol-polycaprolactone amphiphilic diblock copolymers (PEG-PCL) to construct PEG-PCL-MnFe₂O₄ nanomicelles. The characteristics of the MnFe₂O₄ nanoparticles and nanomicelles were tested. Then, MnFe₂O₄ nanoparticles and nanomicelles at different iron concentrations (0, 0.01, 0.02, 0.03, 0.04, 0.06, 0.08, 0.1, 0.2, 0.4, 0.6, 0.8 mmol/L) were placed into EP tubes. Relaxation rate of the nanomicelles were measured using magnetic resonance scanner.
RESULTS AND CONCLUSION: (1) MnFe₂O₄ nanoparticles appeared as round under transmission electron microscopy. The size of nanoparticles was 11 nm with good monodispersion. The Zeta-particle size was (11.18±1.72) nm. The molar ratio of Fe/Mn was 2.13:1. The size of PEG-PCL-MnFe₂O₄ nanomicelles ranged from 52 to 86 nm, with a mean Zeta-particle size of (78.8±12.4) nm. (2) The signal intensity (SI) change of PEG-PCL-MnFe₂O₄ nanomicelles and PEG-PCL-Fe₃O₄nanomicelles shared similar trend according to iron concentration. With the increasing of iron concentration, SI first increased and then decreased in T1WI, and it gradually decreased in T2WI and T2*WI. The SI changes in T2*WI were significantly stronger than that in T2WI and T1WI. Taken together, our results show that PEG-PCL-MnFe₂O₄ nanomicelles are expected to perform as a sensitive contrast agent used in T2WI as their moderate particle size, good monodisperse and strong T₂ relaxation.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Nanostructures, Magnetic Resonance Imaging, Tissue Engineering

CLC Number:

R318

Yang Hua, Gong Ming-fu, Zou Li-guang, Zhang Song, Shu Tong-sheng, Zhou Pei-hua. Synthesis of MnFe₂O₄ nanomicelles and its application in magnetic resonance molecular imaging[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(47): 7090-7096.

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References

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Synthesis of MnFe₂O₄ nanomicelles and its application in magnetic resonance molecular imaging

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