Research progress of metabolism and physiological functions of the lacunar-canalicular system

doi:10.3969/j.issn.2095-4344.2016.42.020

Abstract

Abstract:

BACKGROUND: Interstitial fluid flow around the osteocytes caused by a series of physiological activities plays an important role in the osteocyte metabolism and signal transduction.
OBJECTIVE: To review and summarize the research progress of bone structures and physiological functions, then further illustrate how the mechanical loads make an impact on bone tissue.
METHODS: A computer-based search was conducted in PubMed database for articles related to the bone microstructure, metabolism and osteocyte signal transduction published from January 2009 to December 2015. The keywords were “osteocyte, mechanical load, permeability, lacunar-canalicular system, interstitial fluid flow, mechanotransduction, signaling pathways” in English. Data were screened firstly, dated articles or literatures with wrong research methods were excluded, and totally 40 eligible articles were enrolled.
RESULTS AND CONCLUSION: Bone tissue can quickly adapt to the change of mechanical environment to guarantee enough osteocytes in the functional bone area indicating that osteocytes regulate the bone absorption and formation by responding to stress, which is closely related to osteocyte physiological characters. Osteocytes exist in mineralized matrix, and the special microstructures make it possible to receive mechanical loads and transform the mechanical signals into chemical signals aimed at regulating the bone absorption or formation.So the interstitial fluid flow in the lacuna-canalicular system occures, namely load-induced fluid flow, when the mechanical load is distributed on the bone. This fluid flow affects the bone tissue through two mechanisms: regulating osteocyte metabolism and participating in the mechanotransduction. In conclusion, the mechanical load plays a vital role in maintaining health bone and regulating bone adaptation.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Bone and Bones, Microtubules, Signal Transduction, Tissue Engineering

CLC Number:

R318

Shi Li-jun1, Gao Fu-qiang2, Sun Wei2. Research progress of metabolism and physiological functions of the lacunar-canalicular system[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(42): 6363-6370.

Figures/Tables 1

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