Chinese Journal of Tissue Engineering Research ›› 2016, Vol. 20 ›› Issue (41): 6225-6232.doi: 10.3969/j.issn.2095-4344.2016.41.022

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Recent advances in surface markers of gastric cancer stem cells

Du Hua, Shi Ying-xu   

  1. Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China
  • Revised:2016-08-10 Online:2016-10-07 Published:2016-10-07
  • Contact: Shi Ying-xu, M.D., Assistant researcher, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China
  • About author:Du Hua, Master, Lecturer, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China
  • Supported by:

    Chunhui Plan of the Ministry of Education in China, No. jyb13ch06

Abstract:

BACKGROUND: It has been observed recently that tumor recurrence is closely related to cancer stem cells. Cancer stem cell theory provides a new avenue for the study of gastric cancer pathogenesis, diagnosis and treatment. To determine the cell phenotype is helpful to target gastric cancer stem cells, and contributes to exploring the self-renewal and differentiation of gastric cancer stem cells, further providing new ideas for the treatment of gastric cancer. However, the phenotype of gastric cancer stem cells remains controversial.
OBJECTIVE: To review the research progress in gastric cancer stem cell phenotype.
METHODS: A computer-based online search of PubMed database was performed to search related articles published between January 1965 and October 2015 with the key words of “Gastric Cancer Stem Cells” in English. Sixty-eight articles were included for final analysis.
RESULTS AND CONCLUSION: Traditional cancer stem cell phenotypes are unsuitable for marking gastric cancer stem cells. Studies have found that CD90 expresses in primary gastric cancers, and cancer stem cell spheres would be required via serum-free culture by CD90 maker. CD24 expression can improve the adhesion, invasion and migration of gastric cancer cells. Further studies have confirmed that a lot of cells positive for both CD44 and CD54 can be found in patients with early recurrence of gastric cancer rather than those with advanced recurrence, and CD44 and CD54 expression in tumor cells is likely to be an important cause of gastric cancer occurrence and recurrence. By analyzing the sorting, CD44+CD24+CD90+CD54+ is likely to be the gastric cancer stem cell phenotype.

 

 

Key words: Stomach Neoplasms, Neoplastic Stem Cells, Biological Markers, Tissue Engineering

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