Biocompatibility of a bioabsorbable material in the internal fixation of articular fractures

doi:10.3969/j.issn.2095-4344.2016.34.010

Abstract

Abstract:

BACKGROUND: In recent years, poly-L-lactic acid (PLLA)/polylactic acid copolymer (PLGA)/ hydroxyapatite (HAP) composite bioabsorbable material has achived desired effect in articular fractures.
OBJECTIVE: To investigate the biocompatibility of PLLA/PLGA/HA bioabsorbable material in the internal fixation of articular fractures.
METHODS: In vivo experiment: 22 New Zealand rabbits were enrolled to prepare ankle fracture models, and were then randomly divided into two groups, including composite material group fixed with PLLA/PLGA/HA bioabsorbable material, and metal material group fixed with metal stent. Therapeutic effects and complications were observed at 7 days after surgery. In vitro experiment: PLLA/PLGA/HA bioabsorbable material was co-cultured with MG-63 cells to observe the cell proliferation and adhesion.
RESULTS AND CONCLUSION: In the in vitro experiment, nine rabbits healed well, and two rabbits appeared to have complications in the mental material group; rabbits in the composite material group healed well without any complications. In the in vitro experiment: fusiform-shaped cells all adhered to the composite stent after 1 day of incubation; the number of cells began to increase showing the strong growth ability, and in a tight and regular arrangement at 3 days after incubation; the cytotoxicity was grade 0 or 1 within 1-7 days of incubation. At 3 days of co-culture, fusiform or polygonal cells appeared on the composite material, and these interconnectde cells extended well, and moreover, the frizz parts on the cell surface grew into the composite material, displaying a good adherence. To conclude, as a new bioabsorbable material, PLLA/PLGA/HA exhibits a good biocompatibility.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Fracture Fixation, Hydroxyapatites, Tissue Engineering

CLC Number:

R318

Xie Yang-jiang, Chen En-tao, Wu Bo, Ao Jun. Biocompatibility of a bioabsorbable material in the internal fixation of articular fractures[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(34): 5076-5081.

Figures/Tables 4

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