Stem cells in the skin regeneration and wound healing: problem and perspective

doi:10.3969/j.issn.2095-4344.2016.23.022

Abstract

Abstract:

BACKGROUND: Present treatments for chronic skin wounds have certain limitations, and adult stem cells play a potential part in cutaneous repair and regeneration.
OBJECTIVE: To review effects of stem cells in skin regeneration and wound healing.
METHODS: The first author retrieved CNKI and Medline databases by computer for relevant articles published from 2000 to 2010. The keywords were “epidermal stem cells, hair follicle stem cells, stem cells, transplantation, dermal stem cells” in Chinese and in English, respectively. Then totally 489 papers were obtained after initial survey, and according to the inclusion criteria, 30 articles were selected for review.
RESULTS AND CONCLUSION: Epidermal stem cells and other adult stem cells have been applied to treat wounds and other skin diseases. Epidermal stem cells are the crucial cell source of skin development, repair and remodeling. Epidermal stem cells are always in a resting state in vivo. Unless, skin injure or culture in vitro, cell division and proliferation will be significantly fastened. The stability of the epidermis mainly depends on the asymmetric division of a subpopulation, in which two daughter cells are produced, including one with characteristics of stem cells, and the other differentiated into transient amplifying cells that will be differentiated into post mitotic cells after a series of cell divisions (3-5 times). Afterwards, those post mitotic cells are developed into terminal differentiation cells on the basal layer, finally detach from the epidermis as dander. In addition, it is unclear whether epidermal factors are related to apoptosis, migration and differentiation in the process of wound repair and even under physiological conditions. Therefore, application of stem cells in wound healing requires a further discussion.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Stem Cells, Tissue Engineering, Skin

CLC Number:

R318

Fang Shao-xia, Guo Fen. Stem cells in the skin regeneration and wound healing: problem and perspective[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(23): 3491-3496.

Figures/Tables 2

References

[1] Ko SH, Nauta A, Wong V, et al. The role of stem cells in cutaneous wound healing: what do we really know? Plast Reconstruct Surg. 2011;127(Suppl 1):10S.
[2] An YL, Wei W, Jing H. Bone marrow mesenchymal stem cell aggregate: an optimal cell therapy for full-layer cutaneous wound vascularization and regeneration. Sci Rep. 2015;5:17036.
[3] Trinh NT, Yamashita T, Ohneda K. Increased expression of EGR-1 in diabetic human adipose tissue-derived mesenchymal stem cells reduces their wound healing capacity. Stem Cells Dev. 2016.
[4] Goncalves S, Bas E, Goldstein BJ. Effects of Cell-Based Therapy for Treating Tympanic Membrane Perforations in Mice. Otolaryngol Head Neck Surg. 2016.
[5] Tadeu AM, Horsley V. Epithelial stem cells in adult skin. Curr Top Dev Biol. 2014;107:109-131.
[6] Sakar MS, Eyckmans J. Cellular forces and matrix assembly coordinate fibrous tissue repair.Nat Commun. 2016;7:11036.
[7] Spaas JH, Gomiero C, Broeckx SY, Wound-healing markers after autologous and allogeneic epithelial-like stem cell treatment. Cytotherapy. 2016;18(4):562-569.
[8] Malhotra S, Hu MS, Marshall CD. Mesenchymal stromal cells as cell-based therapeutics for wound healing. Stem Cells Int. 2016;2016:4157934.
[9] Pavan Kumar B, Ram Mohan S, Mohan AP. Versatility of pleuripotent undifferentiated stem cells aspirated from bone marrow and its applications in oral and maxillofacial surgery. J Maxillofac Oral Surg. 2016; 15(1):1-11.
[10] Fathollah S, Mirpour S, Mansouri P. Investigation on the effects of the atmospheric pressure plasma on wound healing in diabetic rats. Sci Rep. 2016;6:19144.
[11] Du L, Lv R, Yang X. Hypoxic conditioned medium of placenta-derived mesenchymal stem cells protects against scar formation. Life Sci. 2016;149:51-57.
[12] Kim SM, Kim YH, Jun YJ. The effect of diabetes on the wound healing potential of adipose-tissue derived stem cells. Int Wound J. 2016;13 Suppl 1:33-41.
[13] Iic D, Vicovac L, Nikolic M. Human amniotic membrane grafts in therapy of chronic non-healing wounds. Br Med Bull. 2016;117(1):59-67.
[14] Sun L, Huang Y, Bian Z. Sundew-inspired adhesive hydrogels combined with adipose-derived stem cells for wound healing. ACS Appl Mater Interfaces. 2016; 8(3):2423-2434.
[15] Doi H, Kitajima Y, Luo L. Potency of umbilical cord blood- and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing. Sci Rep. 2016;6:18844.
[16] Condé-Green A, Marano AA, Lee ES. Fat Grafting and adipose-derived regenerative cells in burn wound healing and scarring: a systematic review of the literature. Plast Reconstr Surg. 2016;137(1):302-312.
[17] Schimke MM, Marozin S, Lepperdinger G. Patient-specific age: the other side of the coin in advanced mesenchymal stem cell therapy. Front Physiol. 2015;6:362.
[18] Fujita K, Kuge K, Ozawa N. Cinnamtannin B-1 promotes migration of mesenchymal stem cells and accelerates wound healing in mice. PLoS One. 2015; 10(12):e0144166.
[19] Hu MS, Leavitt T, Malhotra S. Stem cell-based therapeutics to improve wound healing. Plast Surg Int. 2015;2015:383581.
[20] Marfia G, Navone SE, Di Vito C. Mesenchymal stem cells: potential for therapy and treatment of chronic non-healing skin wounds. Organogenesis. 2015;11(4): 183-206.
[21] Hocking AM. The Role of chemokines in mesenchymal stem cell homing to wounds. Adv Wound Care (New Rochelle). 2015;4(11):623-630.
[22] Tang T, Jiang H, Yu Y. A new method of wound treatment: targeted therapy of skin wounds with reactive oxygen species-responsive nanoparticles containing SDF-1α. Int J Nanomedicine. 2015;10: 6571-6585.
[23] De Giglio E, Bonifacio MA, Cometa S. Exploiting a new glycerol-based copolymer as a route to wound healing: synthesis, characterization and biocompatibility assessment. Colloids Surf B Biointerfaces. 2015; 136: 600-611.
[24] De Giglio E, Cometa S, Ricci MA. Ciprofloxacin- modified electrosynthesized hydrogel coatings to prevent titanium-implant-associated infections. Acta Biomater. 2011;7(2):882-891.
[25] Cometa S, Mattioli-Belmonte M. Antibiotic-modified hydrogel coatings on titanium dental implants.J Biol Regul Homeost Agents. 2012;26(2 Suppl):65-71.
[26] Dai T, Chen Z. Radioresistance of granulation tissue-derived cells from skin wounds combined with total body irradiation. Mol Med Rep. 2016.
[27] Zhao B, Liu JQ, Zheng Z. Human amniotic epithelial stem cells promote wound healing by facilitating migration and proliferation of keratinocytes via ERK, JNK and AKT signaling pathways. Cell Tissue Res. 2016.
[28] Kosaraju R, Rennert RC, Maan ZN. Adipose-derived stem cell-seeded hydrogels increase endogenous progenitor cell recruitment and neovascularization in wounds. Tissue Eng Part A. 2016;22(3-4):295-305.
[29] Whittam AJ, Maan ZN, Duscher D. Challenges and opportunities in drug delivery for wound healing. Adv Wound Care (New Rochelle). 2016;5(2):79-88.
[30] Seo BF, Jung SN.The Immunomodulatory Effects of Mesenchymal Stem Cells in Prevention or Treatment of Excessive Scars. Stem Cells Int. 2016;2016: 6937976.