Three-point bending mechanical properties of the bone in a rat model of osteoporosis after treatment with four kinds of drugs

doi:10.3969/j.issn.2095-4344.2015.46.012

Abstract

Abstract:

BACKGROUND: Mechanical property test is an important method for assessing the therapeutic effect of drug therapy in osteoporosis animal models. But there are rare reports on the three-point bending mechanical test for evaluating the therapeutic effects of a variety of drugs on a female rat model of senile osteoporosis.

OBJECTIVE: To explore the interventional effects of Danqi particles, premarin, ipriflavone and αD3 in a rat model of osteoporosis through the three-point bending mechanical test.

METHODS: Forty-eight female Wistar rats were randomized into six groups, and animal models of senile osteoporosis were made in all rats except for those in the normal control group. Then, the rats were given Danqi particles (0.9g/kg/d), ipriflavone (1 mg/kg/d), αD3 (0.1 mg/ka/d) and premarin (0.3 mg/kg/d) in the Danqi,

ipriflavone, αD3 and premarin groups, respectively. An electronic universal testing machine was used to perform the three-point bending mechanical test on the bilateral tibiae of rats.
RESULTS AND CONCLUSION: Compared with the model group, the maximum load, maximum stress, maximum bending moment, maximum stress, elastic modulus of the tibia were significantly higher in the Danqi, ipriflavone and premarin intervention groups (P < 0.05). There were no significant differences in the maximum load, maximum stress, maximum strain and modulus of elasticity between αD3 and model groups (P > 0.05). There were also no significant differences in the maximum load, maximum stress and maximum strain between the Danqi and normal control groups

(P > 0.05). These findings indicate that Danqi, ipriflavone and premarin interventions have good achievements in the three-point bending mechanical test, and the Danqi particles have the best intervention effects. αD3 has no obvious effects on the three-point bending mechanical performance.
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Osteoporosis, Tibia, Models, Animal, Biomechanics, Tissue Engineering

Yang Qi, Peng Chuan-gang, Wang Ye, Wang Qiang. Three-point bending mechanical properties of the bone in a rat model of osteoporosis after treatment with four kinds of drugs[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(46): 7440-7444.

Figures/Tables 6

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